Chem-0199
Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer.
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- Formule: C13H18N2O2
- Masse moléculaire:234.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Chem-0199 inhibits the binding of AEBP1 to CKAP4 in human/mouse cancer-associated fibroblasts (hCAFs/mCAFs)[1].
Chem-0199 (10-100 μM) inhibits Akt phosphorylation (p-Akt) and downregulates PD-L1 expression in mCAFs[1].
Chem-0199 (10-100 μM, 48 h) significantly increases the proportion of IFN-γ+ and TNF-α+CD8+ T cells and restores T cell cytotoxicity in mouse splenic T cells[1].
Chem-0199 (1-20 μM, 72 h) shows no significant inhibitory effect on the proliferation of multiple tumor cells (MC38, CT26, B16-F10)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT C57BL/6 mice with MC38 tumor [1]
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Dosage:3, 10 and 30 mg/kg
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Administration:Intraperitoneally injection
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Result:Reduced tumor volume.
Further enhanced tumor inhibition and prolonged mouse survival combined with anti-CTLA-4 antibody.
Increased the proportion of IFN-γ+ and TNF-α+CD8+ T cells.
Showed no abnormalities in blood routine (WBC, RBC, Hb, PLT) or H&E staining of heart, liver, lung, kidney, and intestine tissues.
Chemical Information
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Masse moléculaire 234.29
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Formule C13H18N2O2
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SMILES
CC1(C)N(O)[C@H](C2=CC=CC=C2)[N+]([O-])=C1CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chem-0199 Related Classifications
HY-178193 Related Classifications
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