Destruxin A
Based on 1 publication(s) in Google Scholar
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 97.42%
- CAS No.: 6686-70-0
- Formule: C29H47N5O7
- Masse moléculaire:577.71
-
Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Destruxin A
More
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
0.1 μg/mL
Compound: 2
|
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
|
[PMID: 7623030] |
Destruxin A (16 μg/mL; 48 h) exhibits antiproliferative activity against leukemia cell line P388[2].
Destruxin A (0.03-0.33 μg/mL; 48 h) promotes the growth of leukemia cell line P388[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 6686-70-0
-
Appearance Solid
-
Masse moléculaire 577.71
-
Formule C29H47N5O7
-
Color White to off-white
-
SMILES
O=C1[C@]2(N(C([C@@]([H])(CC=C)OC(CCNC([C@@H](N(C([C@@]([H])(N(C([C@@]([H])(N1)[C@H](CC)C)=O)C)C(C)C)=O)C)C)=O)=O)=O)CCC2)[H]
-
Structure Classification
-
Initial Source
Metarhizium anisopliae
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Proc Natl Acad Sci U S A
A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium. [Abstract]2023 Mar 21;120(12):e2205140120. PMID: 36917667
Solvant et solubilité
DMSO : 10 mg/mL (17.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (281 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170. [Content Brief]
[2]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71. [Content Brief]
[3]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7310 mL | 8.6549 mL | 17.3097 mL | 43.2743 mL |
| 5 mM | 0.3462 mL | 1.7310 mL | 3.4619 mL | 8.6549 mL | |
| 10 mM | 0.1731 mL | 0.8655 mL | 1.7310 mL | 4.3274 mL | |
| 15 mM | 0.1154 mL | 0.5770 mL | 1.1540 mL | 2.8850 mL |
Destruxin A Related Classifications
HY-N6689 Related Classifications
Powered by Bioz