The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

  • J Nat Prod. 1995 Apr;58(4):527-31. doi: 10.1021/np50118a007.
H Chen  1 ,  S F Yeh ,  G T Ong ,  S H Wu ,  C M Sun ,  C K Chou
Affiliations
  • 1. Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
PMID: 7623030 DOI: 10.1021/np50118a007
Abstract

We have examined the Antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.