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Cat. No.: HY-N7557

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(E)-2'-Hydroxy-3,4-dimethoxychalcone

(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities.

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CAS No.: 79140-20-8
Formule: C₁₇H₁₆O₄
Masse moléculaire:284.31

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(E)-2'-Hydroxy-3,4-dimethoxychalcone Chemical Structure

CAS No.: 79140-20-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	95 μM Compound: 24	Growth inhibition of MCF7 cells by sulforhodamine assay Growth inhibition of MCF7 cells by sulforhodamine assay	[PMID: 17383189]
MDCK-II	IC₅₀	4.97 μM Compound: 5	Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry	[PMID: 22112540]
Neutrophil	IC₅₀	15 μM Compound: 13	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
Neutrophil	IC₅₀	6.4 μM Compound: 13	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
TK-10	IC₅₀	90 μM Compound: 24	Growth inhibition of TK10 cells by sulforhodamine assay Growth inhibition of TK10 cells by sulforhodamine assay	[PMID: 17383189]

Chemical Information

CAS No. 79140-20-8
Masse moléculaire 284.31
Formule C₁₇H₁₆O₄
SMILES

O=C(C1=CC=CC=C1O)/C=C/C2=CC=C(OC)C(OC)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mauricio Cabrera, et al. Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. Bioorg Med Chem. 2010 Jul 15;18(14):5391-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(E)-2'-Hydroxy-3,4-dimethoxychalcone

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Activité biologique
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(E)-2'-Hydroxy-3,4-dimethoxychalcone

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

(E)-2'-Hydroxy-3,4-dimethoxychalcone Related Classifications

HY-N7557 Related Classifications