(E/Z)-Squalene
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner.
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- CAS No.: 7683-64-9
- Formule: C30H50
- Masse moléculaire:410.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
>50 μM
Compound: 20
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Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay
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[PMID: 20704331] |
| NCI-H460 | IC50 |
>50 μM
Compound: 20
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Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay
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[PMID: 20704331] |
| Neutrophil | IC50 |
>30 μM
Compound: 8
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge
Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge
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[PMID: 19203247] |
| SF-268 | IC50 |
>50 μM
Compound: 20
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Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay
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[PMID: 20704331] |
(E/Z)-Squalene (0-50 μM) reduces intracellular ROS levels in human mammary epithelial cells (MCF10A), prevents H2O2-induced oxidative damage, and protects cells from DNA oxidative damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7683-64-9
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Masse moléculaire 410.72
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Formule C30H50
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SMILES
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C
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Synonyms
(E/Z)-Super Squalene; (E/Z)-AddaVax
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Structure Classification
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Initial Source
Human Blood, Feces, Sweat
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E/Z)-Squalene Related Classifications
HY-N1214A Related Classifications
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