Lpl - lipoprotein lipase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16956

Summary

Enables lipoprotein Lipase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of macrophage derived foam cell differentiation; and triglyceride catabolic process. Acts upstream of or within response to bacterium. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; limb; lung; and sensory organ. Used to study familial lipoprotein Lipase deficiency. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein Lipase). [provided by Alliance of Genome Resources, Apr 2022]

Lpl Products (1)

mRNA Protein Name
NM_008509.2 NP_032535.2 lipoprotein lipase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables lipoprotein lipase activity IDA
IDA: Inferred from direct assay
2563260 MGI
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
15178420 MGI
Biological Process GO Annotation Evidence Références Source
involved in cellular response to fatty acid IDA
IDA: Inferred from direct assay
21986524 MGI
involved in cellular response to nutrient IDA
IDA: Inferred from direct assay
21986524 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IGI
IGI: Inferred from genetic interaction
22963823 MGI
involved in positive regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
22963823 MGI
involved in positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
22963823 MGI
involved in positive regulation of interleukin-6 production IGI
IGI: Inferred from genetic interaction
22963823 MGI
involved in positive regulation of macrophage derived foam cell differentiation IGI
IGI: Inferred from genetic interaction
10858435 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
22963823 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
involved in triglyceride catabolic process IDA
IDA: Inferred from direct assay
15178420 MGI
Cellular Component GO Annotation Evidence Références Source
located in cell surface IDA
IDA: Inferred from direct assay
20620994 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15178420 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lipoprotein lipase

  • O 1-4-5

  • phospholipase A1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P2752 Lipoprotein lipase, Pseudomonas sp / Phase 3
HY-117549 Ibrolipim Activator 99.48% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P4153 Enlicitide chloride Inhibitor 99.11% Unkown
HY-N5015 Rosmanol Inhibitor 98.95% Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-116538 (10E,12Z)-Octadeca-10,12-dienoic acid Activator 99.10% Unkown
HY-101395A W146 TFA 98.22% Unkown
HY-128671 6-​Thioinosine 99.31% Unkown
HY-165607S MCB-22-174 99.78% Unkown
HY-119601 GRI918013 Inhibitor / Unkown
HY-RS07563 LCP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07772 LPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17184 Lpl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23635 Lpl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpl NCBI NCBI:4023