SIK2 - salt inducible kinase 2 Gene

Also Known as QIK; SIK-2; SNF1LK2; LOH11CR1I

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23235

About SIK2

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,602,449-111,730,855 (from NCBI)

This gene has 2 transcripts (splice variants), 231 orthologues and 17 paralogues. Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIK2 Products (2)

mRNA Protein Name
XM_017017417.2 XP_016872906.1 serine/threonine-protein kinase SIK2 isoform X1
NM_015191.3 NP_056006.1 serine/threonine-protein kinase SIK2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables ATP binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16306228 GOA
enables protein serine kinase activity IDA
IDA: Inferred from direct assay
24129571 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14976552 GOA
Biological Process GO Annotation Evidence Références Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
14976552 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
18348280 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14976552 GOA
Cellular Component GO Annotation Evidence Références Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
24129571 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (20 - 271)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK2

  • SNF1-like kinase 2

  • qin-induced kinase

  • salt-inducible protein kinase 2

  • salt-inducible serine/threonine kinase 2

  • serine/threonine-protein kinase SNF1-like kinase 2

SIK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SIK2 Q9H0K1 CEP250 Homo sapiens Q9BV73
Protein Kinase Assay
20708153
Intra
SIK2 Q9H0K1 VCP Homo sapiens P55072
Y2H Array
32814053
Intra
SIK2 Q9H0K1 VCP Homo sapiens P55072
Y2H Pooling
32814053
Intra
SIK2 Q9H0K1 VCP Homo sapiens P55072
TAP
16306228
Intra
SIK2 Q9H0K1 VCP Homo sapiens P55072
Validated Y2H
32814053
Intra
SIK2 Q9H0K1 GABARAPL2 Homo sapiens P60520
Y2H Array
25416956
Intra
SIK2 Q9H0K1 GABARAPL2 Homo sapiens P60520
Y2H Prey Pooling
25416956
Intra
SIK2 Q9H0K1 PIK3R1 Homo sapiens P27986
Protein Kinase Assay
27478041
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Diabetes Mellitus, Non-Insulin-Dependent

  • Type 2 Diabetes

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-120856 ARN-3236 Inhibitor 99.66% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-139253 MRIA9 Inhibitor 98.88% Unkown
HY-175479 GLPG4970 Inhibitor 99.60% Unkown
HY-163743 SIC-19 Inhibitor 98.00% Unkown
HY-148063 DB0614 99.92% Unkown
HY-173191 SK-124 Inhibitor / Unkown
HY-171591 SIK2-IN-4 Inhibitor 99.06% Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-171590 SIK2-IN-3 Inhibitor / Unkown
HY-170237 SIK2/3-IN-1 Inhibitor / Unkown
HY-182804 SIK2/3-IN-3 Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SIK2 RGD RGD:1559698
Canis familiaris SIK2 VGNC VGNC:53440
Bos taurus SIK2 VGNC VGNC:50078
Felis catus SIK2 VGNC VGNC:65143
Mus musculus SIK2 MGD MGI:2445031
Macaca mulatta SIK2 VGNC VGNC:82237
Others SIK2 NCBI