Acat1 - acetyl-CoA acetyltransferase 1 Gene

Also Known as RATACAL

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25014

About Acat1

Primary_assembly 8: 53,979,813-54,008,855 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 202 orthologues, 7 paralogues and is associated with 10 phenotypes. Biased expression in Heart (RPKM 1952.7), Kidney (RPKM 13.6) and 9 other tissues.

Summary

Enables several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; response to hormone; and response to starvation. Located in mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Acat1 Products (2)

mRNA Protein Name
NM_017075.2 NP_058771.2 acetyl-CoA acetyltransferase, mitochondrial precursor
NM_017075.2 NP_058771.2 acetyl-CoA acetyltransferase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables acetyl-CoA C-acetyltransferase activity IDA
IDA: Inferred from direct assay
2478525 RGD
enables coenzyme A binding IPI
IPI: Inferred from physical interaction
1672610 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
1684101 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11988101 RGD
Biological Process GO Annotation Evidence Références Source
involved in adipose tissue development IEP
IEP: Inferred from expression pattern
2866764 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
5166591 RGD
involved in metanephric proximal convoluted tubule development IEP
IEP: Inferred from expression pattern
7733320 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
6144148 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
6489337 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
2985752 RGD
Cellular Component GO Annotation Evidence Références Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
11988101 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
17180682 RGD
NOT located in peroxisome IDA
IDA: Inferred from direct assay
17180682 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acat1 Protein Structure

thiolase

thiolase: cd00751 (39 - 422)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

acetyl-CoA acetyltransferase, mitochondrial

  • acetoacetyl-CoA thiolase

  • acetyl-Co A acetyltransferase 1 mitochondrial

  • acetyl-coenzyme A acetyltransferase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit Effect
Pureté Phase
HY-13215 Avasimibe Inhibitor 99.85% Phase 3
HY-100401 Pactimibe Inhibitor 99.98% Phase 3
HY-100400A K-604 dihydrochloride Inhibitor 99.42% Phase 2
HY-100399A Nevanimibe hydrochloride Inhibitor 99.49% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-100399 Nevanimibe Inhibitor 98.99% Yes
HY-100401A Pactimibe sulfate Inhibitor 98.0% Unkown
HY-N18066 Esculeogenin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acat1 NCBI NCBI:38