1. Metabolic Enzyme/Protease
    Apoptosis
  2. Acyltransferase
    Apoptosis
  3. Nevanimibe hydrochloride

Nevanimibe hydrochloride (Synonyms: PD-132301 hydrochloride; ATR101 hydrochloride)

Cat. No.: HY-100399A Purity: 99.77%
Handling Instructions

Chlorhydrate de névanimibe (chlorhydrate de PD-132301) est un acyl-coenzyme A qui est oralement active et sélectif: inhibiteur cholestérol O-acyltransférase 1 (ACAT1) avec un EC50 de 9 nM. Chlorhydrate de névanimibe inhibe l'ACAT2 avec une CE50 de 368 nM. Chlorhydrate de névanimibe induit l'apoptose cellulaire et a le potentiel de cancer corticosurrénal.

Nevanimibe Hydrochlorid (PD-132301 Hydrochlorid) ist ein oral aktiver und selektiver Acyl-Coenzym A:Cholesterin O-Acyltransferase 1 (ACAT1)-Inhibitor mit einem EC50 von 9 nM. Nevanimibe-Hydrochlorid hemmt ACAT2 mit einem EC50 von 368 nM. Nevanimibe-Hydrochlorid induziert apoptosis und hat das Potenzial für Nebennierenrindenkrebs.

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer.

For research use only. We do not sell to patients.

Nevanimibe hydrochloride Chemical Structure

Nevanimibe hydrochloride Chemical Structure

CAS No. : 133825-81-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 286 In-stock
Estimated Time of Arrival: December 31
5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nevanimibe hydrochloride:

Top Publications Citing Use of Products

View All Acyltransferase Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].

IC50 & Target

ACAT1

9 nM (EC50)

ACAT2

368 nM (EC50)

In Vitro

Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: The H295R and HAC clone 15 (HAC15) human ACC cell lines
Concentration: 3 nM-30 μM
Incubation Time: 24 hours
Result: 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours.
Clinical Trial
Molecular Weight

458.08

Formula

C₂₇H₄₀ClN₃O

CAS No.

133825-81-7

SMILES

O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1830 mL 10.9151 mL 21.8302 mL
5 mM 0.4366 mL 2.1830 mL 4.3660 mL
10 mM 0.2183 mL 1.0915 mL 2.1830 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NevanimibePD-132301ATR101PD132301PD 132301ATR 101ATR-101AcyltransferaseApoptosisDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseorallyactiveacyl-coenzymeA:cholesterolO-acyltransferase1adrenocorticalcancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Nevanimibe hydrochloride
Cat. No.:
HY-100399A
Quantity:
MCE Japan Authorized Agent: