1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. Nevanimibe hydrochloride

Nevanimibe hydrochloride (Synonyms: PD-132301 hydrochloride; ATR101 hydrochloride)

Cat. No.: HY-100399A Purity: 99.77%
Handling Instructions

Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) is a selective and potent acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) inhibits ACAT2 with an EC50 of 368 nM.

For research use only. We do not sell to patients.

Nevanimibe hydrochloride Chemical Structure

Nevanimibe hydrochloride Chemical Structure

CAS No. : 133825-81-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 286 In-stock
Estimated Time of Arrival: December 31
5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Nevanimibe hydrochloride:

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  • Biological Activity

  • Technical Information

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Description

Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) is a selective and potent acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) inhibits ACAT2 with an EC50 of 368 nM[1].

IC50 & Target[1]

ACAT1

9 nM (EC50)

ACAT2

368 nM (EC50)

In Vitro

Coincubation of Nevanimibe (ATR-101; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability[1].

Cell Cytotoxicity Assay[1]

Cell Line: The H295R and HAC clone 15 (HAC15) human ACC cell lines
Concentration: 3 nM-30 μM
Incubation Time: 24 hours
Result: 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1830 mL 10.9151 mL 21.8302 mL
5 mM 0.4366 mL 2.1830 mL 4.3660 mL
10 mM 0.2183 mL 1.0915 mL 2.1830 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

458.08

Formula

C₂₇H₄₀ClN₃O

CAS No.

133825-81-7

SMILES

O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

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C1   V1   C2   V2

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Product Name:
Nevanimibe hydrochloride
Cat. No.:
HY-100399A
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Nevanimibe hydrochloride

Cat. No.: HY-100399A