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Cat. No.: HY-106807

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Litoxetine

(Synonyms: SL 81.0385)

Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT₃ receptor antagonist with a K_i of 85 nM for cerebral 5-HT₃ receptors. Litoxetine is an antidepressant and has antiemetic properties.

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CAS No.: 86811-09-8
Formule: C₁₆H₁₉NO
Masse moléculaire:241.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Litoxetine Chemical Structure

CAS No.: 86811-09-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- Essai clinique
Chemical Information
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.3 μM Compound: Litoxetine	Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells	[PMID: 19282174]
HEK293	IC₅₀	1.4 μM Compound: 4	Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting	[PMID: 19740658]
HEK293	IC₅₀	5.9 nM Compound: 4	Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting	[PMID: 19740658]
HEK293	IC₅₀	6 nM Compound: Litoxetine	Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells	[PMID: 19282174]
HEK293	IC₅₀	6.5 μM Compound: Litoxetine	Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells	[PMID: 19282174]
HEK293	IC₅₀	6.7 μM Compound: 4	Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting	[PMID: 19740658]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 86811-09-8
Masse moléculaire 241.33
Formule C₁₆H₁₉NO
SMILES

C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1
Synonyms

SL 81.0385
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. I Angel, et al. Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232(2-3):139-45. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Litoxetine

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform 5-HT Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

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Litoxetine Related Classifications

HY-106807 Related Classifications