NMDA receptor antagonist 9
NMDA receptor antagonist 9 is a selective GluN2B subunit-containing NMDA receptor antagonist with a Ki of 5.2 nM. NMDA receptor antagonist 9 exhibits 9-fold selectivity over σ1 receptors, shows poor selectivity towards σ2 receptors. NMDA receptor antagonist 9 inhibits ion flux through GluN2B subunit-containing NMDA receptors. NMDA receptor antagonist 9 can be used for the research of neurological disease, such as alzheimer’s disease and parkinson’s disease.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C21H25NO2
- Masse moléculaire:323.43
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform iGluR
MoreVoir tous les produits spécifiques à Isoform Sigma Receptor
More
Activité biologique
|
GluN2B 5.2 nM (Ki) |
σ2 4.2 nM (Ki) |
σ1 49 nM (Ki) |
NMDA receptor antagonist 9 (Compound cis-15a) binds to GluN2B subunit-containing NMDA receptors in recombinant L(tk-) cells with a Ki of 5.2 ± 1.9 nM[1].
NMDA receptor antagonist 9 (1 μM) inhibits ion flux at GluN2B subunit-containing NMDA receptors expressed in Xenopus laevis oocytes by 76 ± 2%[1].
NMDA receptor antagonist 9 binds to σ1 and σ2 receptors in guinea pig brain membranes with a Ki of 49 ± 7 and 4.2 ± 0.6 nM[1].
NMDA receptor antagonist 9 (90 min at 37 °C) exhibits high phase I metabolic stability in mouse liver microsomes, with 89 ± 6% intact after incubation[1].
NMDA receptor antagonist 9 (90 min at 37 °C) retains high metabolic stability in mouse liver microsomes with NADPH and UDP-GA, with 88% intact after incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Masse moléculaire 323.43
-
Formule C21H25NO2
-
SMILES
OC1=CC=C2C(C[C@@H]([C@@H]2O)N3CCC(CC3)CC4=CC=CC=C4)=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NMDA receptor antagonist 9 Related Classifications
HY-181007 Related Classifications
Powered by Bioz
- NMDA receptor antagonist 9
- NMDA receptor antagonist9
- NMDA receptor antagonist-9
- iGluR
- Sigma Receptor
- ischemic stroke
- parkinson’s disease
- GluN2B subunit-containing NMDA receptor
- ifenprodil binding site
- huntington’s disease
- depression
- neuropathic pain
- σ2 receptors
- σ1 receptors
- alzheimer’s disease
- Inhibitor
- inhibitor
- inhibit