Pentagastrin meglumine
Based on 1 publication(s) in Google Scholar
Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor agonist with an EC50 value of 11 nM. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury.
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- CAS No.: 57448-84-7
- Formule: C44H66N8O14S
- Masse moléculaire:963.11
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Pentagastrin meglumine
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Activité biologique
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CCKBR |
Pentagastrin (0.1-100 μM; GH3-cells) meglumine increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold[1].
Pentagastrin (0.1-100 μM; GH3-cells) meglumine bounds dose dependently to GH3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[2]
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Dosage:80 µg/kg/h
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Administration:Intravenous injection
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Result:Protected rat gastric mucosa from acidified aspirin injury.
Induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pHi during acid challenge.
Chemical Information
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CAS No. 57448-84-7
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Masse moléculaire 963.11
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Formule C44H66N8O14S
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SMILES
O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCNC(OC(C)(C)C)=O)=O)CC2=CNC3=C2C=CC=C3.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC
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Synonyms
ICI-50123 meglumine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Mol Biosci
An Integrated Computational and Experimental Approach to Identifying Inhibitors for SARS-CoV-2 3CL Protease. [Abstract]2021 May 17:8:661424. PMID: 34079818
Pureté et documentation
Références
[1]. Smith AJ, et al. Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisation. Eur J Pharmacol. 1994 Apr 15;267(2):215-23. [Content Brief]
[2]. Tanaka S, et al. Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion. Gut. 1998 Sep;43(3):334-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pentagastrin meglumine Related Classifications
HY-A0261A Related Classifications
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