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Cat. No.: HY-184822

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STAT6-IN-14

STAT6-IN-14 is a STAT6 inhibitor that blocks the binding of STAT6-pIL-4Rα, with an IC₅₀ of 1.20 μM. STAT6-IN-14 can inhibit IL-4-induced STAT6 transcriptional activity in STAT6-HEK293 cells. STAT6-IN-14 can be used for research on allergic diseases and inflammation.

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CAS No.: 3033741-74-8
Formule: C₂₉H₂₄F₄N₆O₃
Masse moléculaire:580.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STAT6-IN-14 Chemical Structure

CAS No.: 3033741-74-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Activité biologique

Description

IC₅₀ & Target^[1]

STAT6

1.2 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform STAT :

In Vitro

STAT6-IN-14 (Compound 39) inhibits the binding of human STAT6 to phosphorylated IL-4 receptor α (pIL-4Rα) in a cell‑free system, with an IC₅₀of 1.20 μM (30 min pre‑incubation + 30 min fluorescence polarization detection)^[1].
STAT6-IN-14 (0.1-1 μM; 1 h pre‑incubation + 6 h IL‑4 stimulation) inhibits STAT6‑mediated transcriptional activity in HEK293 cells overexpressing human STAT6, with inhibition rates of 99% at 1 μM and 84% at 0.1 μM, and no significant cytotoxicity is observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK293 cells
Concentration:

0.1 μM
Incubation Time:

1 h pre‑incubation + 6 h IL‑4 stimulation
Result:

Inhibited STAT6-mediated transcriptional activity with an inhibition rate of 84%, and the cell viability was > 70%, indicating no significant cytotoxicity at this concentration.

Chemical Information

CAS No. 3033741-74-8
Masse moléculaire 580.53
Formule C₂₉H₂₄F₄N₆O₃
SMILES

O=C(C1=CC(NC(C2=CC(C(F)(F)F)=CC3=C2N(CC)C(C4=CC=C(N5C(N(C)N=C5C)=O)C=C4)=C3)=O)=CC=C1F)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sumikawa, Y., et al. "Fused Ring Compound and Pharmaceutical Containing the Same." World Intellectual Property Organization, 4 Apr. 2024, WO 2024/071439 A1.

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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STAT6-IN-14

Voir tous les produits spécifiques à Isoform STAT

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Chemical Information

Pureté et documentation

Références

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STAT6-IN-14 Related Classifications

HY-184822 Related Classifications