2. Apoptosis MAPK/ERK Pathway
  3. Apoptosis p38 MAPK
  4. Chromium picolinate

Chromium picolinate  (Synonyms: Chromium (III) picolinate; Cr(Pic)3)

Cat. No.: HY-125588 Purity: 99.40%
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Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.

For research use only. We do not sell to patients.

Chromium picolinate Chemical Structure

Chromium picolinate Chemical Structure

CAS No. : 14639-25-9

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Chromium picolinate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chromium picolinate

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Description

Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes[1][2][3][4].

In Vitro

Chromium picolinate (5-100 μM, 24-72 h) induces lymphocyte apoptosis through ROS and mitochondrial events[1].
Chromium picolinate (100 nM, 24 h) exerts hypoglycemic effects in insulin-resistant 3T3-L1 adipocytes by activating p38 MAPK[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chromium picolinate Related Antibodies

Cell Viability Assay[1]

Cell Line: lymphocytes
Concentration: 5,10, 25, 50, 75, 100 μM
Incubation Time: 24-72 h
Result: Inhibited cell viability from concentration of 25 μM.

Western Blot Analysis[1]

Cell Line: lymphocytes
Concentration: 50, 100 μM
Incubation Time: 24 h
Result: Increased the expression of Bax. and cytochrome.
Increased the activity of caspase-3.
In Vivo

Chromium picolinate (100 mg/kg/day, orally, once daily for 4 weeks) causes weight gain and improves insulin sensitivity in Goto-Kakizaki diabetic rats[3].
Chromium picolinate (1 mg/kg/day, orally, once a daily for 4 weeks) can reduce the oxidative stress response of hyperglycemia induced by streptozotocin (HY-13753) in diabetic rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Goto-Kakizaki diabetic rats [3]
Dosage: 100 mg/kg
Administration: p.o.
Result: Increased body weight.
The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats.
Animal Model: Streptozotocin-induced diabetic rats[4]
Dosage: 1 mg/kg
Administration: p.o.
Result: Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats.
Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.
Clinical Trial
Molecular Weight

418.30

Formula

C18H12CrN3O6
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

O=C1[O-][Cr+3]([N]2=C(C=CC=C2)C3=O)([O-]3)([N]4=C(C=CC=C4)C5=O)([O-]5)[N]6=C1C=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 7.81 mg/mL (18.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3906 mL 11.9531 mL 23.9063 mL
5 mM 0.4781 mL 2.3906 mL 4.7813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3906 mL 11.9531 mL 23.9063 mL 59.7657 mL
5 mM 0.4781 mL 2.3906 mL 4.7813 mL 11.9531 mL
10 mM 0.2391 mL 1.1953 mL 2.3906 mL 5.9766 mL
15 mM 0.1594 mL 0.7969 mL 1.5938 mL 3.9844 mL
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Chromium picolinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chromium picolinate14639-25-9Chromium (III) picolinate Cr(Pic)3Apoptosisp38 MAPKActivitorLymphocytes3T3-L1Diabetic ratsInhibitorinhibitorinhibit

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