Cat. No.: HY-125588

Chromium picolinate

(Synonyms: Chromium (III) picolinate; Cr(Pic)3)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.

For research use only. We do not sell to patients.

Purity: 99.76%
CAS No.: 14639-25-9
Formula: C₁₈H₁₂CrN₃O₆
Molecular Weight:418.30

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Chromium picolinate Chemical Structure

CAS No.: 14639-25-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All p38 MAPK Isoforms :

In Vitro

Chromium picolinate (5-100 μM, 24-72 h) induces lymphocyte apoptosis through ROS and mitochondrial events^[1].
Chromium picolinate (100 nM, 24 h) exerts hypoglycemic effects in insulin-resistant 3T3-L1 adipocytes by activating p38 MAPK^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

lymphocytes
Concentration:

5,10, 25, 50, 75, 100 μM
Incubation Time:

24-72 h
Result:

Inhibited cell viability from concentration of 25 μM.

Western Blot Analysis^[1]

Cell Line:

lymphocytes
Concentration:

50, 100 μM
Incubation Time:

24 h
Result:

Increased the expression of Bax. and cytochrome.
Increased the activity of caspase-3.

In Vivo

Chromium picolinate (100 mg/kg/day, orally, once daily for 4 weeks) causes weight gain and improves insulin sensitivity in Goto-Kakizaki diabetic rats^[3].
Chromium picolinate (1 mg/kg/day, orally, once a daily for 4 weeks) can reduce the oxidative stress response of hyperglycemia induced by streptozotocin (HY-13753) in diabetic rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Goto-Kakizaki diabetic rats ^[3]
Dosage:

100 mg/kg
Administration:

p.o.
Result:

Increased body weight.
The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats.

Animal Model:

Streptozotocin-induced diabetic rats^[4]
Dosage:

1 mg/kg
Administration:

p.o.
Result:

Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats.
Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 14639-25-9
Appearance Solid
Molecular Weight 418.30
Formula C₁₈H₁₂CrN₃O₆
Color Pink to red
SMILES

O=C1[O-][Cr+3]([N]2=C(C=CC=C2)C3=O)([O-]3)([N]4=C(C=CC=C4)C5=O)([O-]5)[N]6=C1C=CC=C6
Synonyms

Chromium (III) picolinate; Cr(Pic)3
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

Cell Biol Toxicol

TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension. [Abstract]

2025 Jul 1;41(1):110. PMID: 40591004
Biol Trace Elem Res

Antagonizing Effects of Chromium Against Iron-Decreased Glucose Uptake by Regulating ROS-Mediated PI3K/Akt/GLUT4 Signaling Pathway in C2C12. [Abstract]

2024 Feb;202(2):701-712. PMID: 37156991
Clin Immunol

PLK2 facilitates Mycobacterium tuberculosis clearance via p38 MAPK-mediated ROS production. [Abstract]

2026 Jun:285:110705. PMID: 41962814

Solvent & Solubility

In Vitro:

DMSO : 7.81 mg/mL (18.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3906 mL

11.9531 mL

23.9063 mL

5 mM

0.4781 mL

2.3906 mL

4.7813 mL

10 mM

0.2391 mL

1.1953 mL

2.3906 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jana M, et al. Chromium picolinate induced apoptosis of lymphocytes and the signaling mechanisms thereof. Toxicol Appl Pharmacol. 2009 Jun 15;237(3):331-44. [Content Brief]

[2]. Wang YQ, et al. Effects of chromium picolinate on glucose uptake in insulin-resistant 3T3-L1 adipocytes involve activation of p38 MAPK. J Nutr Biochem. 2009 Dec;20(12):982-91. [Content Brief]

[3]. Kim DS, et al. Chromium picolinate supplementation improves insulin sensitivity in Goto-Kakizaki diabetic rats. J Trace Elem Med Biol. 2004;17(4):243-7. [Content Brief]

[4]. Sundaram B, et al. Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats. J Trace Elem Med Biol. 2013 Apr;27(2):117-21. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3906 mL	11.9531 mL	23.9063 mL	59.7657 mL
	5 mM	0.4781 mL	2.3906 mL	4.7813 mL	11.9531 mL
	10 mM	0.2391 mL	1.1953 mL	2.3906 mL	5.9766 mL
	15 mM	0.1594 mL	0.7969 mL	1.5938 mL	3.9844 mL

Keywords

Chromium picolinate

3 Cited Publications

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Chromium picolinate

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Publications Citing Use of MedChemExpress (MCE) Chromium picolinate

All p38 MAPK Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Chromium picolinate Related Classifications

HY-125588 Related Classifications