Chromium picolinate
Based on 4 publication(s) in Google Scholar
Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.76%
- CAS. Nr.: 14639-25-9
- Formel: C18H12CrN3O6
- Molecular Weight:418.30
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chromium picolinate
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Biologische Aktivität
Beschreibung
In Vitro
Chromium picolinate (5-100 μM, 24-72 h) induces lymphocyte apoptosis through ROS and mitochondrial events[1].
Chromium picolinate (100 nM, 24 h) exerts hypoglycemic effects in insulin-resistant 3T3-L1 adipocytes by activating p38 MAPK[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:lymphocytes
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Concentration:5,10, 25, 50, 75, 100 μM
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Incubation Time:24-72 h
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Result:Inhibited cell viability from concentration of 25 μM.
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Cell Line:lymphocytes
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Concentration:50, 100 μM
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Incubation Time:24 h
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Result:Increased the expression of Bax. and cytochrome. Increased the activity of caspase-3.
In Vivo
Chromium picolinate (1 mg/kg/day, orally, once a daily for 4 weeks) can reduce the oxidative stress response of hyperglycemia induced by streptozotocin (HY-13753) in diabetic rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Goto-Kakizaki diabetic rats [3]
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Dosage:100 mg/kg
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Administration:p.o.
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Result:Increased body weight. The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats.
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Animal Model:Streptozotocin-induced diabetic rats[4]
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Dosage:1 mg/kg
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Administration:p.o.
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Result:Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats. Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 14639-25-9
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Appearance Solid
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Molecular Weight 418.30
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Formel C18H12CrN3O6
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Color Pink to red
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SMILES
O=C1[O-][Cr+3]([N]2=C(C=CC=C2)C3=O)([O-]3)([N]4=C(C=CC=C4)C5=O)([O-]5)[N]6=C1C=CC=C6
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Synonyms
Chromium (III) picolinate; Cr(Pic)3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Biol Toxicol
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension. [Abstract]2025 Jul 1;41(1):110. PMID: 40591004 -
Biol Trace Elem Res
Antagonizing Effects of Chromium Against Iron-Decreased Glucose Uptake by Regulating ROS-Mediated PI3K/Akt/GLUT4 Signaling Pathway in C2C12. [Abstract]2024 Feb;202(2):701-712. PMID: 37156991 -
Clin Immunol
PLK2 facilitates Mycobacterium tuberculosis clearance via p38 MAPK-mediated ROS production. [Abstract]2026 Jun:285:110705. PMID: 41962814
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 7.81 mg/mL (18.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (287 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Jana M, et al. Chromium picolinate induced apoptosis of lymphocytes and the signaling mechanisms thereof. Toxicol Appl Pharmacol. 2009 Jun 15;237(3):331-44. [Content Brief]
[2]. Wang YQ, et al. Effects of chromium picolinate on glucose uptake in insulin-resistant 3T3-L1 adipocytes involve activation of p38 MAPK. J Nutr Biochem. 2009 Dec;20(12):982-91. [Content Brief]
[3]. Kim DS, et al. Chromium picolinate supplementation improves insulin sensitivity in Goto-Kakizaki diabetic rats. J Trace Elem Med Biol. 2004;17(4):243-7. [Content Brief]
[4]. Sundaram B, et al. Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats. J Trace Elem Med Biol. 2013 Apr;27(2):117-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3906 mL | 11.9531 mL | 23.9063 mL | 59.7657 mL |
| 5 mM | 0.4781 mL | 2.3906 mL | 4.7813 mL | 11.9531 mL | |
| 10 mM | 0.2391 mL | 1.1953 mL | 2.3906 mL | 5.9766 mL | |
| 15 mM | 0.1594 mL | 0.7969 mL | 1.5938 mL | 3.9844 mL |
Chromium picolinate Related Classifications
HY-125588 Related Classifications
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