CR 665
Based on 2 publication(s) in Google Scholar
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 228546-92-7
- Formula: C36H49N9O4
- Molecular Weight:671.83
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CR 665
MoreAll Opioid Receptor Isoforms
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Biological Activity
C50: 10.9 nM (κ-opioid)[1]
CR 665 exhibits high peripheral to central nervous system (CNS) selectivity[1].
CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 228546-92-7
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Appearance Solid
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Molecular Weight 671.83
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Formula C36H49N9O4
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Color White to off-white
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Synonyms
JNJ 38488502; FE 200665
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons. [Abstract]2025 Dec 24;188(26):7547-7570.e45 PMID: 41406962 -
Solvent & Solubility
DMSO : 100 mg/mL (148.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Anne E Olesen, et al. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet [Content Brief]
[2]. Francis M Hughes Jr, et al. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4885 mL | 7.4424 mL | 14.8847 mL | 37.2118 mL |
| 5 mM | 0.2977 mL | 1.4885 mL | 2.9769 mL | 7.4424 mL | |
| 10 mM | 0.1488 mL | 0.7442 mL | 1.4885 mL | 3.7212 mL | |
| 15 mM | 0.0992 mL | 0.4962 mL | 0.9923 mL | 2.4808 mL | |
| 20 mM | 0.0744 mL | 0.3721 mL | 0.7442 mL | 1.8606 mL | |
| 25 mM | 0.0595 mL | 0.2977 mL | 0.5954 mL | 1.4885 mL | |
| 30 mM | 0.0496 mL | 0.2481 mL | 0.4962 mL | 1.2404 mL | |
| 40 mM | 0.0372 mL | 0.1861 mL | 0.3721 mL | 0.9303 mL | |
| 50 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7442 mL | |
| 60 mM | 0.0248 mL | 0.1240 mL | 0.2481 mL | 0.6202 mL | |
| 80 mM | 0.0186 mL | 0.0930 mL | 0.1861 mL | 0.4651 mL | |
| 100 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3721 mL |
CR 665 Related Classifications
HY-P3609 Related Classifications
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