228546-92-7
228546-92-7
Chemical Structure
CR 665
Synonym(s): JNJ 38488502; FE 200665
- CAS No.: 228546-92-7
- Formula:C36H49N9O4
- Molecular Weight:671.83
InChIKey: DBOGGOVKHSCMNB-OMRVPHBLSA-N
SMILES: O=C(NCC1=CC=NC=C1)[C@@H](CCCNC(N)=N)NC([C@@H](CCCC)NC([C@H](NC([C@H](N)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O
Biological Activity: CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CR 665 | 99.66% | CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain. | ||||||||||||||||||||
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References
- [1]. Anne E Olesen, et al. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet [Content Brief]
- [2]. Francis M Hughes Jr, et al. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22. [Content Brief]
Keywords
