2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. CVN417

CVN417 is an orally active α6 subunit-containing nAChR antagonist, modulating phasic dopaminergic neurotransmission in an impulse-dependent manner. CVN417 inhibits Ca(2+) effluents mediated by nAChR subunits with IC50s of 0.086 μM (α6), 2.56 μM (α3) and 0.657 μM (α4), respectively. CVN417 attenuates resting tremor in Rodent models, displays the potential to improve movement dysfunction, in conditions such as Parkinson's disease.

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CVN417

CVN417 Chemical Structure

CAS No. : 2919851-73-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

CVN417 Related Antibodies

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  • Purity & Documentation

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Description

CVN417 is an orally active α6 subunit-containing nAChR antagonist, modulating phasic dopaminergic neurotransmission in an impulse-dependent manner. CVN417 inhibits Ca(2+) effluents mediated by nAChR subunits with IC50s of 0.086 μM (α6), 2.56 μM (α3) and 0.657 μM (α4), respectively. CVN417 attenuates resting tremor in Rodent models, displays the potential to improve movement dysfunction, in conditions such as Parkinson's disease[1].

IC50 & Target

IC50: 0.086 μM (nAChR α6), 2.56 μM (nAChR α3), 0.657 μM (nAChR α4)[1]
In Vitro

CVN417 (10 μM; 0-2 h) shows low metabolic turnover in human liver microparticles or hepatocytes[1].

In Vitro ADME Data for CVN417[1]

human rat mouse dog
liver microsomes Clint (μL/min/mg) 2.8 31.2 33.3 27.7
hepatocytes (mL/min/106 cells) 3.7 20.8 25.1 32.3

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CVN417 Related Antibodies
In Vivo

CVN417 (3 mg/kg, 10 mg/kg, 25 mg/kg; po) shows a dose-dependent decrease of tremulous jaw movement duration in Rat tacrine tremor model[1].
Pharmacokinetic Analysis of CVN417 in Rat Model[1]

Route Dose (mg/kg) Cl (mL/min/kg) Vdss (L/kg) AUC0-∞ (ng·h/mL) Cmax (μM) F (%) T1/2 (h) Cbrain,total (2 h) Kp, Kpu/u
i.v. 0.5 38.2 12.3 205
p.o. 10 0.35 775 11 5.9 1.82 4.1, 1.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

362.85

Formula

C18H23ClN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(C=CC(OC)=C1)C2=CC(C(N[C@@H]3CN(CCC3)C)=O)=NN2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (275.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7560 mL 13.7798 mL 27.5596 mL
5 mM 0.5512 mL 2.7560 mL 5.5119 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7560 mL 13.7798 mL 27.5596 mL 68.8990 mL
5 mM 0.5512 mL 2.7560 mL 5.5119 mL 13.7798 mL
10 mM 0.2756 mL 1.3780 mL 2.7560 mL 6.8899 mL
15 mM 0.1837 mL 0.9187 mL 1.8373 mL 4.5933 mL
20 mM 0.1378 mL 0.6890 mL 1.3780 mL 3.4449 mL
25 mM 0.1102 mL 0.5512 mL 1.1024 mL 2.7560 mL
30 mM 0.0919 mL 0.4593 mL 0.9187 mL 2.2966 mL
40 mM 0.0689 mL 0.3445 mL 0.6890 mL 1.7225 mL
50 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3780 mL
60 mM 0.0459 mL 0.2297 mL 0.4593 mL 1.1483 mL
80 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.8612 mL
100 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6890 mL
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CVN417 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CVN4172919851-73-1CVN 417CVN-417nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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