1. Metabolic Enzyme/Protease
    MAPK/ERK Pathway
  2. Proteasome
    Ribosomal S6 Kinase (RSK)
  3. DD1

DD1 

Cat. No.: HY-120035
Handling Instructions

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation.

For research use only. We do not sell to patients.

DD1 Chemical Structure

DD1 Chemical Structure

CAS No. : 187585-11-1

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Description

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].

In Vitro

DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1].
DD1 induces cell cycle arrest at G2/M phase and apoptosis[1].
DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1].
DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.29

Formula

C16H14N2O3

CAS No.
SMILES

O=C1C(N)=C(C2=CC=C(OC)C(N)=C2)OC3=CC=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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