2. Metabolic Enzyme/Protease MAPK/ERK Pathway Apoptosis
  3. Proteasome Ribosomal S6 Kinase (RSK) Apoptosis
  4. DD1

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation.

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DD1 Chemical Structure

DD1 Chemical Structure

CAS No. : 187585-11-1

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Based on 1 publication(s) in Google Scholar

DD1 Related Antibodies

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Description

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].

IC50 & Target

p70S6K

 

In Vitro

DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1].
DD1 induces cell cycle arrest at G2/M phase and apoptosis[1].
DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1].
DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DD1 Related Antibodies
Molecular Weight

282.29

Formula

C16H14N2O3
CAS No.
SMILES

O=C1C(N)=C(C2=CC=C(OC)C(N)=C2)OC3=CC=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DD1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DD1187585-11-1DD 1DD-1ProteasomeRibosomal S6 Kinase (RSK)ApoptosisS6Kproteasome inhibitorBax activationP70S6K degradationacute myeloid leukemiaapoptosismitochondrial membrane depolarizationBad dephosphorylationInhibitorinhibitorinhibit

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