1. Anti-infection
  2. HIV
  3. DDX3-IN-2

DDX3-IN-2 

Cat. No.: HY-121969
Handling Instructions

DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance.

For research use only. We do not sell to patients.

DDX3-IN-2 Chemical Structure

DDX3-IN-2 Chemical Structure

CAS No. : 1919828-81-1

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Description

DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance[1].

IC50 & Target[1]

HIV

 

In Vitro

DDX3-IN-2 behaves as a competitive inhibitor with respect to the RNA substrate, which can be seen by the decrease in its inhibition potency as a function of increasing RNA substrate concentrations. DDX3-IN-2 is found to be completely inactive against the ATPase of DDX3, DDX1 helicase, and DENV NS3 helicase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DDX3-IN-2 (20 mg/kg; tail vein injection) possesses excellent biocompatibility, and Wistar rats shows a good tolerance to the dose of 20 mg/kg[1].
DDX3-IN-2 (10 mg/kg; i.v. bolus injection; 0~25 hours) rapidly eliminates the half-life elimination and the plasmatic clearance values[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[1]
Dosage: Tail vein injection
Administration: 20 mg/kg
Result: Possessed excellent biocompatibility, and Wistar rats showed a good tolerance to the dose of 20 mg/kg.
Animal Model: Rats[1]
Dosage: I.v. bolus injection (Pharmacokinetic Analysis)
Administration: 10 mg/kg; 0~25 hours
Result: Rapidly eliminated the half-life elimination and the plasmatic clearance values.
Molecular Weight

349.43

Formula

C₂₀H₂₃N₅O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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DDX3-IN-2
Cat. No.:
HY-121969
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