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Art. -Nr.: HY-175608

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EGFR-IN-171

EGFR-IN-171 is an EGFR inhibitor with an IC₅₀ value of 0.19 μM. EGFR-IN-171 also inhibits vascular endothelial growth factor 2 (VEGFR-2) with an IC₅₀ value of 31.65 μM. EGFR-IN-171 can induce apoptosis and G2/M phase cell cycle arrest. EGFR-IN-171 can be used for cancer research, such as liver and breast cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₂H₂₆N₄O₃S
Molecular Weight:546.64

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

EGFR-IN-171 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

Alle EGFR Isoform-spezifische Produkte anzeigen :

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

EGFR-IN-171 (Compound 6b) shows cytotoxic in HepG-2, MCF-7 and HCT-116 cells with IC₅₀ vales of 5.8, 3.91 and 7.97 μM, respectively^[1].
EGFR-IN-171 (3.91 μM, 24 h) increases apoptosis and cell accumulation in the G2/M phase in MCF-7 cells^[1].
EGFR-IN-171 (3.91 μM, 24 h) increases Bax and p53 levels and decreases Bcl-2 levels in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

3.91 μM
Incubation Time:

24 h
Result:

Led to a notable increase in late apoptosis from 0.18% to 15.39%.
Increased early apoptosis from 0.35% to 8.92%.
Displayed a 6.3-fold rise in Bax levels.
Increased the amount of p53 protein by 7.2 times.
Downregulated Bcl-2 levels by 2.6 times.

Chemical Information

Molecular Weight 546.64
Formel C₃₂H₂₆N₄O₃S
SMILES

O=C1N(C2=CC=CC=C2)C(SC3=COC(C)=C3C4CC(C5=CC=CO5)NC6=CC=CC=C6N4)=NC7=C1C=CC=C7
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Soliman SM, et al. Design, antiproliferative potency, and in silico studies of novel 5-methylfuran-3-yl)thio)-3-phenylquinazolin-4(3H)-one based derivatives as potential EGFR inhibitors. Sci Rep. 2025 Jul 31;15(1):27992. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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EGFR-IN-171

Alle EGFR Isoform-spezifische Produkte anzeigen

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

EGFR-IN-171 Related Classifications

HY-175608 Related Classifications