(-)-2-Phenylpropylamine
Based on 1 Customer Validation
(-)-2-Phenylpropylamine ((S)-2-Phenylpropylamine) (compound 3b) is a MAO-A and MAO-B inhibitor with Ki values of 584 μM and 156 μM, respectively.
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- Reinheit: 98.44%
- CAS. Nr.: 17596-79-1
- Formel: C9H13N
- Molecular Weight:135.21
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Lösungsmittel & Löslichkeit
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Biologische Aktivität
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MAO-A 584 μM (Ki) |
MAO-B 156 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
129 nM
Compound: 40
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Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay
Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay
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[PMID: 18602830] |
Chemical Information
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CAS. Nr. 17596-79-1
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Appearance Liquid
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Molecular Weight 135.21
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Formel C9H13N
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Color Colorless to light yellow
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SMILES
NC[C@H](C1=CC=CC=C1)C
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Synonyms
(S)-2-Phenylpropylamine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (739.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (36.98 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (36.98 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (417 KB)
- English - EN (417 KB)
- Français - FR (417 KB)
- Deutsch - DE (417 KB)
- Norwegian - NO (417 KB)
- Español - ES (417 KB)
- Swedish - SV (417 KB)
- Italian - IT (417 KB)
- Korean - KR (417 KB)
- Portuguese - PT (417 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.3959 mL | 36.9795 mL | 73.9590 mL | 184.8976 mL |
| 5 mM | 1.4792 mL | 7.3959 mL | 14.7918 mL | 36.9795 mL | |
| 10 mM | 0.7396 mL | 3.6980 mL | 7.3959 mL | 18.4898 mL | |
| 15 mM | 0.4931 mL | 2.4653 mL | 4.9306 mL | 12.3265 mL | |
| 20 mM | 0.3698 mL | 1.8490 mL | 3.6980 mL | 9.2449 mL | |
| 25 mM | 0.2958 mL | 1.4792 mL | 2.9584 mL | 7.3959 mL | |
| 30 mM | 0.2465 mL | 1.2327 mL | 2.4653 mL | 6.1633 mL | |
| 40 mM | 0.1849 mL | 0.9245 mL | 1.8490 mL | 4.6224 mL | |
| 50 mM | 0.1479 mL | 0.7396 mL | 1.4792 mL | 3.6980 mL | |
| 60 mM | 0.1233 mL | 0.6163 mL | 1.2327 mL | 3.0816 mL | |
| 80 mM | 0.0924 mL | 0.4622 mL | 0.9245 mL | 2.3112 mL | |
| 100 mM | 0.0740 mL | 0.3698 mL | 0.7396 mL | 1.8490 mL |
(-)-2-Phenylpropylamine Related Classifications
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