CIDEA - cell death inducing DFFA like effector a Gene

Also Known as CIDE-A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1149

About CIDEA

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,254,361-12,277,595 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 3 paralogues. Restricted expression toward fat (RPKM 78.2).

Summary

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate Apoptosis. This activation of Apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by Caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

CIDEA Products (2)

mRNA Protein Name
NM_001279.4 NP_001270.1 cell death activator CIDE-A isoform 1
NM_001318383.2 NP_001305312.1 cell death activator CIDE-A isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in lipid droplet fusion IDA
IDA: Inferred from direct assay
19843876 GOA
involved in lipid storage IDA
IDA: Inferred from direct assay
19843876 GOA
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
15919794 GOA
involved in negative regulation of lipid catabolic process IDA
IDA: Inferred from direct assay
26118629 GOA
involved in negative regulation of lipid catabolic process IMP
IMP: Inferred from mutant phenotype
15919794 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
15919794 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with lipid droplet IDA
IDA: Inferred from direct assay
18509062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIDEA Protein Structure

CIDE-N

CIDE-N: CIDE-N domain (34 - 109)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

cell death activator CIDE-A

Related Diseases

Diseases Alias
Lipomatosis, Multiple Symmetric

  • Multiple Symmetric Lipomatosis

  • Lipomatosis, Familial Benign Cervical

  • Lipomatosis, Multiple Symmetrical

  • Lipodystrophy, Cephalothoracic

  • Benign Symmetrical Lipomatosis

  • Madelung Disease

  • Madelung'S Disease

  • MSL

  • Cervical Symmetrical Lipomatosis

  • Launois-Bensaude'S Lipomatosis

  • Madelung'S Neck

  • Multiple Symmetrical Lipomatosis

  • Familial Symmetric Lipomatosis

  • Launois-Bensaude Syndrome

  • Cephalothoracic Lipodystrophy

  • Familial Benign Cervical Lipomatosis

  • Launois-Bensaude Lipomatosis
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N9933 Tauro-β-muricholic acid 99.91% Unkown
HY-Y0598 trans-Chalcone 99.25% Unkown
HY-183094 AM73 / Unkown
HY-183095 AM79 / Unkown
HY-183096 AM31 / Unkown
HY-RS02711 CIDEA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19419 Cidea Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25910 Cidea Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CIDEA VGNC VGNC:39271
Macaca mulatta CIDEA VGNC VGNC:104219
Rattus norvegicus CIDEA RGD RGD:1305106
Bos taurus CIDEA VGNC VGNC:106691
Mus musculus CIDEA MGD MGI:1270845
Others CIDEA NCBI