SRMS - src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Gene

Also Known as SRM; PTK70; C20orf148; dJ697K14.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6725

About SRMS

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,538,489-63,547,749 (from NCBI)

This gene has 1 transcript (splice variant), 149 orthologues and 32 paralogues. Broad expression in prostate (RPKM 1.4), stomach (RPKM 1.2) and 15 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in peptidyl-tyrosine autophosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SRMS Products (1)

mRNA Protein Name
NM_080823.4 NP_543013.1 tyrosine-protein kinase Srms

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23822091 GOA
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
25897081 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
23822091 GOA
Biological Process GO Annotation Evidence References Source
involved in peptidyl-tyrosine autophosphorylation IDA
IDA: Inferred from direct assay
23822091 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
29496907 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35927303 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23822091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRMS Protein Structure

SH3_9

SH3_9: Variant SH3 domain (58 - 107)

SH2

SH2: SH2 domain (120 - 197)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (232 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase Srms

SRMS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRMS Q9H3Y6 DOK1 Homo sapiens Q99704
Pull Down
23822091
Intra
SRMS Q9H3Y6 DOK1 Homo sapiens Q99704
Anti Bait CoIP
23822091
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Rhabdomyosarcoma

  • Rhabdomyosarcoma Of The Prostate
Prostate Sarcoma

  • Sarcoma Of The Prostate
Spindle Cell Rhabdomyosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-120111A MW-150 hydrochloride Inhibitor / Phase 2
HY-120111B MW-150 dihydrochloride dihydrate Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131028 Janelia Fluor® 646 TFA 97.79% Unkown
HY-131029 Janelia Fluor® 646, Maleimide 97.50% Unkown
HY-120111 MW-150 Inhibitor 99.89% Unkown
HY-P3146A FTISADTSK acetate 99.66% Unkown
HY-131026 Janelia Fluor® 635, SE 99.30% Unkown
HY-P3146S FTISADTSK-13C6,15N2 TFA 96.04% Unkown
HY-RS13769 SRM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-152901 Chol-N3 / Unkown
HY-120796 MW108 hydrochloride Inhibitor / Unkown
HY-P3146 FTISADTSK / Unkown
HY-RS13770 SRMS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18332 Srm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22333 Srms Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24811 Srm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28855 Srms Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SRMS MGD MGI:101865
Macaca mulatta SRMS VGNC VGNC:108062
Canis familiaris SRMS VGNC VGNC:46806
Felis catus SRMS VGNC VGNC:65682
Rattus norvegicus SRMS RGD RGD:1306602
Bos taurus SRMS VGNC VGNC:35283
Others SRMS NCBI