1. MAPK/ERK Pathway
  2. p38 MAPK
  3. MW-150 dihydrochloride dihydrate

MW-150 dihydrochloride dihydrate (Synonyms: MW01-18-150SRM dihydrochloride dihydrate)

Cat. No.: HY-120111B
Handling Instructions

MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM.

For research use only. We do not sell to patients.

MW-150 dihydrochloride dihydrate Chemical Structure

MW-150 dihydrochloride dihydrate Chemical Structure

CAS No. : 1661020-92-3

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10 mg USD 550 Get quote
50 mg USD 1650 Get quote
100 mg USD 2650 Get quote

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Other Forms of MW-150 dihydrochloride dihydrate:

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  • Biological Activity

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Description

MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM[1].

IC50 & Target[1]

p38α

101 nM (Ki)

In Vitro

MW-150 dihydrochloride dihydrate inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
MW-150 dihydrochloride dihydrate blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].

In Vivo

MW-150 dihydrochloride dihydrate (2.5 mg/kg; oral daily for 3−4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 dihydrochloride dihydrate (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (42.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0390 mL 10.1951 mL 20.3903 mL
5 mM 0.4078 mL 2.0390 mL 4.0781 mL
10 mM 0.2039 mL 1.0195 mL 2.0390 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

490.43

Formula

C₂₄H₂₉Cl₂N₅O₂

CAS No.

1661020-92-3

SMILES

CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.Cl.O.Cl.O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MW-150 dihydrochloride dihydrate
Cat. No.:
HY-120111B
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MW-150 dihydrochloride dihydrate

Cat. No.: HY-120111B