1661020-92-3
Chemical Structure
MW-150 dihydrochloride dihydrate
Synonym(s): MW01-18-150SRM dihydrochloride dihydrate
- CAS No.: 1661020-92-3
- Formula:C24H29Cl2N5O2
- Molecular Weight:490.43
IUPAC Name: 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine dihydrochloride dihydrate
InChIKey: URBRIDWUCWBFOU-UHFFFAOYSA-N
SMILES: CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.Cl.O.Cl.O
Biological Activity: MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
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MW-150 dihydrochloride dihydrate | MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia. | |||||||||||||||||||||
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Keywords
