MW-150 hydrochloride
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
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- CAS No.: 1923773-01-6
- Formule: C24H24ClN5
- Masse moléculaire:417.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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p38α 101 nM (Ki) |
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta) [1]
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Dosage:2.5 mg/kg
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Administration:Oral daily; 3-4 months (until cognitive impairment is present)
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Result:Improved the Tg mice performance in both cognitive tests.
Chemical Information
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CAS No. 1923773-01-6
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Masse moléculaire 417.93
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Formule C24H24ClN5
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SMILES
CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.[H]Cl
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Synonyms
MW01-18-150SRM hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MW-150 hydrochloride Related Classifications
HY-120111A Related Classifications
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