1. MAPK/ERK Pathway
  2. p38 MAPK
  3. MW-150 hydrochloride

MW-150 hydrochloride (Synonyms: MW01-18-150SRM hydrochloride)

Cat. No.: HY-120111A
Handling Instructions

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM.

For research use only. We do not sell to patients.

MW-150 hydrochloride Chemical Structure

MW-150 hydrochloride Chemical Structure

CAS No. : 1923773-01-6

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Description

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM[1].

IC50 & Target[1]

p38α

101 nM (Ki)

In Vitro

MW-150 hydrochloride inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
MW-150 hydrochloride blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].

In Vivo

MW-150 hydrochloride (2.5 mg/kg; oral daily for 3−4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 hydrochloride (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].

Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta) [1]
Dosage: 2.5 mg/kg
Administration: Oral daily; 3-4 months (until cognitive impairment is present)
Result: Improved the Tg mice performance in both cognitive tests.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

417.93

Formula

C₂₄H₂₄ClN₅

CAS No.

1923773-01-6

SMILES

CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MW-150 hydrochloride
Cat. No.:
HY-120111A
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MW-150 hydrochloride

Cat. No.: HY-120111A