1. MAPK/ERK Pathway
    Autophagy
  2. p38 MAPK
    Autophagy
  3. MW-150

MW-150 (Synonyms: MW01-18-150SRM)

Cat. No.: HY-120111 Purity: 98.23%
Handling Instructions

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.

For research use only. We do not sell to patients.

MW-150 Chemical Structure

MW-150 Chemical Structure

CAS No. : 1628502-91-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].

IC50 & Target

p38α

101 nM (Ki)

In Vitro

MW-150 inhibits in a concentration-dependent manner the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
MW-150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].

In Vivo

MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].

Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1]
Dosage: 2.5 mg/kg
Administration: Oral daily; 3-4 months (until cognitive impairment is present)
Result: Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
Molecular Weight

381.47

Formula

C₂₄H₂₃N₅

CAS No.

1628502-91-9

SMILES

CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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MW-150
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