1. MAPK/ERK Pathway
  2. p38 MAPK
  3. MW-150

MW-150 (Synonyms: MW01-18-150SRM)

Cat. No.: HY-120111
Handling Instructions

MW150 (MW01-18-150SRM) is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM.

For research use only. We do not sell to patients.

MW-150 Chemical Structure

MW-150 Chemical Structure

CAS No. : 1628502-91-9

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Description

MW150 (MW01-18-150SRM) is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM[1].

IC50 & Target[1]

p38α

101 nM (Ki)

In Vitro

MW150 inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
MW150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].

In Vivo

MW150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].

Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1]
Dosage: 2.5 mg/kg
Administration: Oral daily; 3-4 months (until cognitive impairment is present)
Result: Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

381.47

Formula

C₂₄H₂₃N₅

CAS No.

1628502-91-9

SMILES

CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

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MW-150
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MW-150

Cat. No.: HY-120111