1923773-01-6
Chemical Structure
MW-150 hydrochloride
Synonym(s): MW01-18-150SRM hydrochloride
- CAS No.: 1923773-01-6
- Formula:C24H24ClN5
- Molecular Weight:417.93
IUPAC Name: 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine hydrochloride
InChIKey: FQMOEAOQYORXPF-UHFFFAOYSA-N
SMILES: CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.[H]Cl
Biological Activity: MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
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MW-150 hydrochloride | MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia. | |||||||||||||||||||||
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