DOK1 - docking protein 1 Gene

Also Known as pp62; P62DOK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1796

About DOK1

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,549,105-74,557,551 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 6.6), spleen (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is part of a signal transduction pathway downstream of Receptor Tyrosine Kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DOK1 Products (6)

mRNA Protein Name
NM_001197260.2 NP_001184189.1 docking protein 1 isoform b
NM_001318866.2 NP_001305795.1 docking protein 1 isoform b
NM_001318867.2 NP_001305796.1 docking protein 1 isoform c
NM_001318868.2 NP_001305797.1 docking protein 1 isoform d
NM_001318869.2 NP_001305798.1 docking protein 1 isoform e
NM_001381.5 NP_001372.1 docking protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
23822091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK1 Protein Structure

IRS

IRS: PTB domain (IRS-1 type) (152 - 253)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

docking protein 1

  • Downstream of tyrosine kinase 1

DOK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
DOK1 Q99704 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
DOK1 Q99704 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
DOK1 Q99704 SRMS Homo sapiens Q9H3Y6
Anti Bait CoIP
23822091
Intra
DOK1 Q99704 SRMS Homo sapiens Q9H3Y6
Protein Kinase Assay
23822091
Intra
DOK1 Q99704 SRMS Homo sapiens Q9H3Y6
Anti Tag CoIP
23822091
Cross: Cross-species interaction Intra: Intraspecies interaction

DOK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83123 DOK1 Antibody (YA2868) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Myopia 28, Autosomal Recessive

  • MYP28
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03933 DOK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01046 ART4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19593 Dok1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19875 Art4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26089 Dok1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DOK1 MGD MGI:893587
Bos taurus DOK1 VGNC VGNC:28165
Canis familiaris DOK1 VGNC VGNC:40055
Rattus norvegicus DOK1 RGD RGD:1309499
Macaca mulatta DOK1 VGNC VGNC:71968
Felis catus DOK1 VGNC VGNC:61580
Others DOK1 NCBI