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Isoplumbagin

Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function.

For research use only. We do not sell to patients.

CAS No.: 14777-17-4
Formula: C₁₁H₈O₃
Molecular Weight:188.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Isoplumbagin Chemical Structure

CAS No.: 14777-17-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function^[1].

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	GI₅₀	2.7 μM Compound: 2	Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
CAL-51	GI₅₀	2.5 μM Compound: 2	Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCC1954	GI₅₀	0.34 μM Compound: 2	Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCT-116	GI₅₀	0.46 μM Compound: 2	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
K562	GI₅₀	1.3 μM Compound: 2	Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MCF7	GI₅₀	1.4 μM Compound: 2	Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MOLM-13	GI₅₀	4.1 μM Compound: 2	Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MV4-11	GI₅₀	26.5 μM Compound: 2	Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
NCI-H1299	IC₅₀	1.5 μM Compound: 143	Cytotoxicity against human NCI-H1299 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human NCI-H1299 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]
PC-3	IC₅₀	6 μM Compound: 143	Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]
U-87MG ATCC	IC₅₀	2.4 μM Compound: 143	Cytotoxicity against human U87 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human U87 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]

Chemical Information

CAS No. 14777-17-4
Molecular Weight 188.18
Formula C₁₁H₈O₃
SMILES

O=C1C(C)=CC(C2=C1C(O)=CC=C2)=O
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsao YC, et al. Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone. Int J Mol Sci. 2020 Jun 19;21(12):4378. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Isoplumbagin

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All Antibiotic Isoforms