country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-106470

Copy Link Print Information

Difenamizole

(Synonyms: Pasalin)

Difenamizole (Pasalin) is an orally active pyrazole non-steroidal anti-inflammatory agent and pain inhibitor, which capable of crossing the blood-brain barrier. Difenamizole inhibits the release of catecholamines by monoaminergic neurons, reduces the concentrations of dopamine metabolites and normetanephrine (NE) in the striatum, and thereby regulates the levels of dopamine and norepinephrine in the brain. Difenamizole is not only antagonized by dopamine in the brain, but also exerts synergistic effects with Oxidopamine (6-OHDA) (HY-B1081/A), Phenoxybenzamine (HY-B0431), Reserpine (HY-N0480), and other agents. Difenamizole inhibits conditioned, emotional and aggressive behaviors in rodents, and can be used in studies of pain and related neurobehaviors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 20170-20-1
Formel: C₂₀H₂₂N₄O
Molecular Weight:334.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Difenamizole Chemical Structure

CAS. Nr.: 20170-20-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

Difenamizole (25-150 mg/kg; p.o.; single dose) alters cerebral catecholamine and metabolite levels in healthy male ddY mice, including dose-dependent increases in dien-+mesencephalic NE and significant decreases in striatal 3-MT and dien-+mesencephalic NM^[1].
Difenamizole (50 mg/kg; p.o.; single dose) significantly reduces striatal 3-MT and HVA concentrations 60 minutes post-administration in healthy male ddY mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY (male, 20-22 g)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; single dose
Result:

Increased striatal dopamine levels to 4735.2 ng/g wet weight.
Decreased striatal 3-MT levels to 218.8 ng/g wet weight.
Decreased striatal homovanillic acid (HVA) levels to 461.0 ng/g wet weight.

Chemical Information

CAS. Nr. 20170-20-1
Molecular Weight 334.42
Formel C₂₀H₂₂N₄O
SMILES

O=C(NC1=CC(=NN1C=2C=CC=CC2)C=3C=CC=CC3)C(N(C)C)C
Synonyms

Pasalin
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nabeshima T, et al. Effects of difenamizole on content of catecholamines and metabolites in mouse brain[J]. The Japanese Journal of Pharmacology, 1978, 28(4): 642-646.

[2]. Saleem BAA, et al.. Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity. RSC advances. 2026 Jun 02;16(33):30052-30069. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Difenamizole

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Difenamizole Related Classifications

HY-106470 Related Classifications