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Cat. No.: HY-106470

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Difenamizole

(Synonyms: Pasalin)

Difenamizole (Pasalin) is an orally active pyrazole non-steroidal anti-inflammatory agent and pain inhibitor, which capable of crossing the blood-brain barrier. Difenamizole inhibits the release of catecholamines by monoaminergic neurons, reduces the concentrations of dopamine metabolites and normetanephrine (NE) in the striatum, and thereby regulates the levels of dopamine and norepinephrine in the brain. Difenamizole is not only antagonized by dopamine in the brain, but also exerts synergistic effects with Oxidopamine (6-OHDA) (HY-B1081/A), Phenoxybenzamine (HY-B0431), Reserpine (HY-N0480), and other agents. Difenamizole inhibits conditioned, emotional and aggressive behaviors in rodents, and can be used in studies of pain and related neurobehaviors.

For research use only. We do not sell to patients.

CAS No.: 20170-20-1
Formula: C₂₀H₂₂N₄O
Molecular Weight:334.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Difenamizole Chemical Structure

CAS No.: 20170-20-1

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Biological Activity

Description

All Dopamine Receptor Isoforms :

In Vivo

Difenamizole (25-150 mg/kg; p.o.; single dose) alters cerebral catecholamine and metabolite levels in healthy male ddY mice, including dose-dependent increases in dien-+mesencephalic NE and significant decreases in striatal 3-MT and dien-+mesencephalic NM^[1].
Difenamizole (50 mg/kg; p.o.; single dose) significantly reduces striatal 3-MT and HVA concentrations 60 minutes post-administration in healthy male ddY mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY (male, 20-22 g)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; single dose
Result:

Increased striatal dopamine levels to 4735.2 ng/g wet weight.
Decreased striatal 3-MT levels to 218.8 ng/g wet weight.
Decreased striatal homovanillic acid (HVA) levels to 461.0 ng/g wet weight.

Chemical Information

CAS No. 20170-20-1
Molecular Weight 334.42
Formula C₂₀H₂₂N₄O
SMILES

O=C(NC1=CC(=NN1C=2C=CC=CC2)C=3C=CC=CC3)C(N(C)C)C
Synonyms

Pasalin
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nabeshima T, et al. Effects of difenamizole on content of catecholamines and metabolites in mouse brain[J]. The Japanese Journal of Pharmacology, 1978, 28(4): 642-646.

[2]. Saleem BAA, et al.. Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity. RSC advances. 2026 Jun 02;16(33):30052-30069. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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Difenamizole

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Difenamizole Related Classifications

HY-106470 Related Classifications