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Cat. No.: HY-N15081

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5-N-Acetylardeemin

5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent Vinblastine (HY-13780) in multidrug resistant human tumor cells.

For research use only. We do not sell to patients.

CAS No.: 148441-26-3
Formula: C₂₈H₂₈N₄O₃
Molecular Weight:468.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

5-N-Acetylardeemin Chemical Structure

CAS No.: 148441-26-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent Vinblastine (HY-13780) in multidrug resistant human tumor cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	106.7 μM Compound: 24	Cytotoxicity against human KB cells assessed as cell growth inhibition Cytotoxicity against human KB cells assessed as cell growth inhibition	[PMID: 36375335]

Chemical Information

CAS No. 148441-26-3
Molecular Weight 468.55
Formula C₂₈H₂₈N₄O₃
SMILES

C=CC(C)([C@]12[C@](N(C3=CC=CC=C32)C(C)=O)([H])N4[C@@](C(N5[C@@H](C4=O)C)=NC6=CC=CC=C6C5=O)([H])C1)C
Structure Classification
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- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daigo Hayashi, et al. Synthesis and ABCG2 inhibitory evaluation of 5-N-acetylardeemin derivatives. Bioorg Med Chem. 2015 May 1;23(9):2010-23. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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