L-Ascorbic acid sodium salt
Based on 81 publication(s) in Google Scholar
L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.01%
- CAS No.: 134-03-2
- Formula: C6H7NaO6
- Molecular Weight:198.11
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications Citing Use of MedChemExpress (MCE) L-Ascorbic acid sodium salt
More- Cancer Cell. 2024 Apr 8;42(4):682-700.e12. [Abstract]
- Nat Immunol. 2023 Feb;24(2):280-294. [Abstract]
- Adv Mater. 2024 Dec 26:e2415543. [Abstract]
- Mil Med Res. 2020 Nov 1;7(1):52. [Abstract]
- Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X. [Abstract]
- ACS Nano. 2025 Mar 18;19(10):10180-10198. [Abstract]
- Nat Commun. 2025 Jul 18;16(1):6621. [Abstract]
- Bone Res. 2025 Mar 3;13(1):30. [Abstract]
- J Adv Res. 2025 May 10:S2090-1232(25)00309-1. [Abstract]
- Biomaterials. 2024 Aug 15:313:122756. [Abstract]
- Redox Biol. 2022 Aug;54:102392. [Abstract]
- Mater Today Bio. 2025 Jun 21:33:102009. [Abstract]
- J Neuroinflammation. 2025 Sep 24;22(1):211. [Abstract]
- Sci China Life Sci. 2018 Oct;61(10):1151-1167. [Abstract]
- Acta Neuropathol. 2026 Mar 16;151(1):26. [Abstract]
- Chin Herb Med. 2026 Mar 1.
- Virtual Phys Prototyp. 2026 Mar 1;21.
- Int J Biol Macromol. 2025 May 15:144179. [Abstract]
- Int J Biol Macromol. 2024 Jan;256(Pt 1):127779. [Abstract]
- Free Radic Biol Med. 2020 Feb 1;147:220-230. [Abstract]
- Mater Today Adv. 2026 Feb 10.
- Biomed Pharmacother. 2022 Sep:153:113558. [Abstract]
- Redox Rep. 2024 Dec;29(1):2428147. [Abstract]
- Antioxidants (Basel). 2024 May 27;13(6):653. [Abstract]
- Ind Crops Prod. 2025 Oct 18;237:122143.
- J Agric Food Chem. 2025 Jun 4;73(22):13891-13901. [Abstract]
- Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. [Abstract]
- Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]
- Food Biosci. 2025 Sep 18;73:107628.
- Eur J Med Chem. 2022 Mar 5:231:114151. [Abstract]
- Cell Biol Toxicol. 2023 Jun;39(3):679-702. [Abstract]
- J Ethnopharmacol. 2024 Nov 29:340:119128. [Abstract]
- Food Funct. 2022 May 10;13(9):5089-5101. [Abstract]
- Int J Mol Sci. 2025 Feb 5;26(3):1334. [Abstract]
- Bioorg Chem. 2025 Jan 5:155:108133. [Abstract]
- Bioorg Chem. 2024 May:146:107261. [Abstract]
- Bioorg Chem. 2021 Oct:115:105177. [Abstract]
- Biosci Rep. 2019 May 21;39(5):BSR20182137. [Abstract]
- Front Cell Dev Biol. 2022 Feb 10:10:810327. [Abstract]
- Environ Toxicol Pharmacol. 2026 Mar:122:104954. [Abstract]
- FASEB J. 2020 Sep;34(9):11474-11487. [Abstract]
- J Cell Mol Med. 2020 Apr;24(7):4212-4222. [Abstract]
- iScience. 2024 Feb 5;27(3):109111. [Abstract]
- J Cell Physiol. 2024 May;239(5):e31215. [Abstract]
- Hematol Oncol. 2024 Jul;42(4):e3295. [Abstract]
- J Biol Chem. 2023 Dec;299(12):105462. [Abstract]
- J Nat Prod. 2022 Jul 22;85(7):1808-1815. [Abstract]
- Mol Med Rep. 2019 Dec; 20(6): 4933–4942. [Abstract]
- Cell Cycle. 2023 Feb;22(4):476-493. [Abstract]
- J Neurosci Res. 2019 Dec;97(12):1689-1705. [Abstract]
- J Sex Med. 2018 Feb;15(2):136-147. [Abstract]
- IUBMB Life. 2024 Oct;76(10):832-844. [Abstract]
- Environ Toxicol. 2021 Apr;36(4):520-529. [Abstract]
- Mol Pharmacol. 2025 Nov;107(11):100078. [Abstract]
- J Orthop Surg Res. 2025 Nov 14;20(1):997. [Abstract]
- J Orthop Surg Res. 2025 Oct 29;20(1):943. [Abstract]
- J Orthop Surg Res. 2025 Apr 15;20(1):379. [Abstract]
- Genes (Basel). 2024 Sep 13;15(9):1206. [Abstract]
- Mol Biol Rep. 2024 Mar 14;51(1):421. [Abstract]
- Fitoterapia. 2021 Sep:153:104984. [Abstract]
- Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923. [Abstract]
- J Mol Histol. 2024 Aug;55(4):503-512. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149770. [Abstract]
- Drug Chem Toxicol. 2024 May;47(3):347-355. [Abstract]
- Anim Biotechnol. 2024 Nov;35(1):2404043. [Abstract]
- J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913. [Abstract]
- Biol Pharm Bull. 2025;48(6):895-907. [Abstract]
- Cytotechnology. 2021 Dec;73(6):787-800. [Abstract]
- Biol Methods Protoc. 2025 Feb 13;10(1):bpaf012. [Abstract]
- Pak J Pharm Sci. 2026 Jan;39(1):102-116. [Abstract]
- bioRxiv. 2026 May 19.
- SSRN. 2026 Mar 20.
- Res Sq. 2025 Oct 27.
- bioRxiv. 2025 August 25.
- Res Sq. 2025 Jul 21.
- SSRN. 2025 Jan 14.
- Med Rev (2021). 2024 Jun 14;4(6):531-543. [Abstract]
- Research Square Print. 2022 Aug.
- Oxid Med Cell Longev. 2022 Jan 27:2022:7502632. [Abstract]
- J Afr Ass Physiol Sci. 7(1): 30-37, July 2019.
- Nigerian Journal of Scientific Research. 18 (3): 2019.
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2D/3D Cell Culture and Differentiation
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Cell Proliferation/Viability Assay
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WB
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IHC
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WB
All Calcium Channel Isoforms
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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T-type calcium channel |
Microbial Metabolite |
The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 134-03-2
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Appearance Solid
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Molecular Weight 198.11
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Formula C6H7NaO6
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Color White to light yellow
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SMILES
O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O
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Synonyms
Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (81)
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Journal Impact Factor
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Most Recent
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Cancer Cell
PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. [Abstract]2024 Apr 8;42(4):682-700.e12. PMID: 38428409 -
Nat Immunol
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy. [Abstract]2023 Feb;24(2):280-294. PMID: 36543960 -
Adv Mater
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. [Abstract]2024 Dec 26:e2415543. PMID: 39726077 -
Mil Med Res
Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors. [Abstract]2020 Nov 1;7(1):52. PMID: 33129359 -
Cell Host Microbe
2024 Dec 12:S1931-3128(24)00444-X. PMID: 39706182 -
ACS Nano
Starfish-Inspired Synergistic Reinforced Hydrogel Wound Dressing: Dual Responsiveness and Enhanced Bioactive Compound Delivery for Advanced Skin Regeneration and Management. [Abstract]2025 Mar 18;19(10):10180-10198. PMID: 40048360 -
Nat Commun
2025 Jul 18;16(1):6621. PMID: 40681515 -
Bone Res
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]2025 Mar 3;13(1):30. PMID: 40025004 -
J Adv Res
Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes. [Abstract]2025 May 10:S2090-1232(25)00309-1. PMID: 40354935 -
Biomaterials
Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study. [Abstract]2024 Aug 15:313:122756. PMID: 39182327
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 15:313:122756. [Abstract]
(A) Representative images of Alizarin Red staining on 14 and 21 days of BMSCs seeded on porous tantalum scaffolds and cultured in osteogenic induction medium containing 1 M β-glycerophosphate (β-Glycerophosphate disodium salt pentahydrate) and 10 mM ascorbic acid ( L-Ascorbic acid). (B) Quantitative analysis of dissolved calcium nodules after 14 days and 21 days (n = 4).
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Redox Biol
Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model. [Abstract]2022 Aug;54:102392. PMID: 35797799 -
Mater Today Bio
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis. [Abstract]2025 Jun 21:33:102009. PMID: 40673132 -
J Neuroinflammation
Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation. [Abstract]2025 Sep 24;22(1):211. PMID: 40993793 -
Sci China Life Sci
2018 Oct;61(10):1151-1167. PMID: 30159682 -
Acta Neuropathol
2026 Mar 16;151(1):26. PMID: 41838122 -
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Int J Biol Macromol
Trained immunity driven by Enterococcus faecalis ribosomal protein S11 enhances antigen presentation and boosts influenza vaccine efficacy via nanoparticle delivery. [Abstract]2025 May 15:144179. PMID: 40381785 -
Int J Biol Macromol
Ligand "switching on" fluorescence of HIV-1 RNA-templated copper nanoclusters for ligand-RNA interaction assays. [Abstract]2024 Jan;256(Pt 1):127779. PMID: 37981280 -
Free Radic Biol Med
Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum. [Abstract]2020 Feb 1;147:220-230. PMID: 31883976 -
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Biomed Pharmacother
2022 Sep:153:113558. PMID: 36076621 -
Redox Rep
Inhibition of SLC40A1 represses osteoblast formation via inducing iron accumulation and activating the PERK/ATF4/CHOP pathway mediated oxidative stress. [Abstract]2024 Dec;29(1):2428147. PMID: 39607819 -
Antioxidants (Basel)
Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells. [Abstract]2024 May 27;13(6):653. PMID: 38929092
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 27;13(6):653. [Abstract]
L-Ascorbic acid (Vitamin C) (50-500 μM; 6 h) significantly increases the viability of heat-stressed gastric cancer cells at concentrations of 200 μM and 300 μM.
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J Agric Food Chem
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway. [Abstract]2025 Jun 4;73(22):13891-13901. PMID: 40404584 -
Antioxid Redox Signal
Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit. [Abstract]2020 Dec 10;33(17):1191-1208. PMID: 32336105
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. [Abstract]
L-Ascorbic acid (Vitamin C) (250 μM, 1 h) significantly alleviates the growth suppression induced by combined SAS and PAG treatment only in OVISE cells, but shows no effect in KOC-7C cells.
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Cancer Cell Int
Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma. [Abstract]2024 May 31;24(1):192. PMID: 38822322
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]
L-Ascorbic acid (AA) (150 μL of 1.5 M; i.p.; every two days) enhances the expression of GPX4 and SLC7A11 proteins in mouse liver.
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]
L-Ascorbic acid (AA) (150ul of 1.5 M; i.p.; every two days) significantly decreases the expression of Ki67 in C57BL/6 mice.
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Eur J Med Chem
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents. [Abstract]2022 Mar 5:231:114151. PMID: 35123296 -
Cell Biol Toxicol
CaMKII and CaV3.2 T-type calcium channel mediate Connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain. [Abstract]2023 Jun;39(3):679-702. PMID: 34286406
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cell Biol Toxicol. 2023 Jun;39(3):679-702. [Abstract]
L-Ascorbic acid (300 μM, 10 μL intrathecal injection) reduces the levels of CaV3.2, p-CaMKII, and Cx43 in mice.
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J Ethnopharmacol
Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice. [Abstract]2024 Nov 29:340:119128. PMID: 39617084 -
Food Funct
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production. [Abstract]2022 May 10;13(9):5089-5101. PMID: 35411884
L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Food Funct. 2022 May 10;13(9):5089-5101. [Abstract]
L-Ascorbic acid (Vitamin C) (100 μM; 10 min-4 h) upregulates the protein expression levels of IGF-1, p-IGF-1R, and SVCT2 in a time-dependent manner.
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Int J Mol Sci
Synergistic Effects of a Novel Combination of Natural Compounds Prevent H2O2-Induced Oxidative Stress in Red Blood Cells. [Abstract]2025 Feb 5;26(3):1334. PMID: 39941102 -
Bioorg Chem
Discovery of potent antiosteoporotic cyclic depsipeptides with an unusual nitrile hydroxy acid from Microascus croci. [Abstract]2025 Jan 5:155:108133. PMID: 39798453 -
Bioorg Chem
Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs. [Abstract]2024 May:146:107261. PMID: 38460336 -
Bioorg Chem
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway. [Abstract]2021 Oct:115:105177. PMID: 34303035 -
Biosci Rep
Autologous decellularized extracellular matrix protects against H2O2-induced senescence and aging in adipose-derived stem cells and stimulates proliferation in vitro. [Abstract]2019 May 21;39(5):BSR20182137. PMID: 31048361 -
Front Cell Dev Biol
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis. [Abstract]2022 Feb 10:10:810327. PMID: 35223839 -
Environ Toxicol Pharmacol
2026 Mar:122:104954. PMID: 41644025 -
FASEB J
Hydrogen sulfide attenuates renal fibrosis by inducing TET-dependent DNA demethylation on Klotho promoter. [Abstract]2020 Sep;34(9):11474-11487. PMID: 32729950 -
J Cell Mol Med
Different culture method changing CD105 expression in amniotic fluid MSCs without affecting differentiation ability or immune function. [Abstract]2020 Apr;24(7):4212-4222. PMID: 32119193 -
iScience
Modeling the precise interaction of glioblastoma with human brain region-specific organoids. [Abstract]2024 Feb 5;27(3):109111. PMID: 38390494 -
J Cell Physiol
Dynamic changes of endothelial and stromal cilia are required for the maintenance of corneal homeostasis. [Abstract]2024 May;239(5):e31215. PMID: 38308657 -
Hematol Oncol
TET2 regulates extranodal NK/T cell lymphoma progression through regulation of DNA methylation. [Abstract]2024 Jul;42(4):e3295. PMID: 38979860 -
J Biol Chem
c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6. [Abstract]2023 Dec;299(12):105462. PMID: 37977223 -
J Nat Prod
Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes. [Abstract]2022 Jul 22;85(7):1808-1815. PMID: 35796002 -
Mol Med Rep
Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair. [Abstract]2019 Dec; 20(6): 4933–4942. PMID: 31661134 -
Cell Cycle
METTL3-mediated long non-coding RNA MIR99AHG methylation targets miR-4660 to promote bone marrow mesenchymal stem cell osteogenic differentiation. [Abstract]2023 Feb;22(4):476-493. PMID: 36369887 -
J Neurosci Res
Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein. [Abstract]2019 Dec;97(12):1689-1705. PMID: 31420910 -
J Sex Med
Changes in Male Rat Sexual Behavior and Brain Activity Revealed by Functional Magnetic Resonance Imaging in Response to Chronic Mild Stress. [Abstract]2018 Feb;15(2):136-147. PMID: 29275048 -
IUBMB Life
Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice. [Abstract]2024 Oct;76(10):832-844. PMID: 39012196 -
Environ Toxicol
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes. [Abstract]2021 Apr;36(4):520-529. PMID: 33166055 -
Mol Pharmacol
LZ-106 inhibits anchorage-independent growth of non-small cell lung cancer cells by a positive feedback between reactive oxygen species induction and autophagy flux blockage. [Abstract]2025 Nov;107(11):100078. PMID: 41110219 -
J Orthop Surg Res
RNA-sequencing-based elucidation of the mechanism underlying aFGF mediated regulation of BMSCs via the PI3K-AKT pathway and its implications for rotator cuff injury repair. [Abstract]2025 Nov 14;20(1):997. PMID: 41239461 -
J Orthop Surg Res
Functional mechanism and clinical implications of miR-455-5p in delayed fracture healing. [Abstract]2025 Oct 29;20(1):943. PMID: 41163026 -
J Orthop Surg Res
Investigation on the role of Icariin in tendon injury repair: focusing on tendon stem cell differentiation. [Abstract]2025 Apr 15;20(1):379. PMID: 40234966 -
Genes (Basel)
CHIR99021 and Brdu Are Critical in Chicken iPSC Reprogramming via Small-Molecule Screening. [Abstract]2024 Sep 13;15(9):1206. PMID: 39336797 -
Mol Biol Rep
ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3β/β-catenin pathway. [Abstract]2024 Mar 14;51(1):421. PMID: 38483756 -
Fitoterapia
2021 Sep:153:104984. PMID: 34216691 -
Clin Exp Pharmacol Physiol
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling. [Abstract]2024 Nov;51(11):e13923. PMID: 39358837 -
J Mol Histol
2024 Aug;55(4):503-512. PMID: 38801643 -
Biochem Biophys Res Commun
Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models. [Abstract]2024 May 14:708:149770. PMID: 38518722 -
Drug Chem Toxicol
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM2.5 treated with vitamin C. [Abstract]2024 May;47(3):347-355. PMID: 36815321 -
Anim Biotechnol
Vitamin C enhances the in vitro development of early porcine embryos by improving mitochondrial function. [Abstract]2024 Nov;35(1):2404043. PMID: 39306701 -
J Pharmacol Toxicol Methods
Establishment of drug screening in human embryonic stem cells based on a high-content screening system. [Abstract]Nov-Dec 2020;106:106913. PMID: 32822830 -
Biol Pharm Bull
Anti-osteoporosis Activity of Sodium Glucuronate in Preosteo-blast MC3T3-E1 Cells and an Ovariectomized Rat Model. [Abstract]2025;48(6):895-907. PMID: 40571633 -
Cytotechnology
Substrate coated with autologous decellularized extracellular matrix facilitates in vitro spreading of spheroid from adipose-derived stem cells through regulating ERK1/2-MMP2/9 pathway. [Abstract]2021 Dec;73(6):787-800. PMID: 34776629 -
Biol Methods Protoc
Optimizing drug sensitivity assays in patient-derived tumor organoids: a comparison of IC50 estimation methods and experimental parameters. [Abstract]2025 Feb 13;10(1):bpaf012. PMID: 40060949 -
Pak J Pharm Sci
Syringaresinol inhibits ferroptosis and ameliorates glucocorticoid-induced MC3T3-E1 osteoporosis by modulating the Nrf2/SLC7A11/GPX4 pathway. [Abstract]2026 Jan;39(1):102-116. PMID: 41482780 -
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Med Rev (2021)
2024 Jun 14;4(6):531-543. PMID: 39664081 -
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Oxid Med Cell Longev
miR-154-5p Affects the TGF β 1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1. [Abstract]2022 Jan 27:2022:7502632. PMID: 35126820 -
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Solvent & Solubility
H2O : 100 mg/mL (504.77 mM; Need ultrasonic)
DMSO : 1 mg/mL (5.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (252.39 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]
[2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]
[3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [Content Brief]
[4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [Content Brief]
[5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [Content Brief]
[6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.0477 mL | 25.2385 mL | 50.4770 mL | 126.1925 mL |
| 5 mM | 1.0095 mL | 5.0477 mL | 10.0954 mL | 25.2385 mL | |
| H2O | 10 mM | 0.5048 mL | 2.5239 mL | 5.0477 mL | 12.6193 mL |
| 15 mM | 0.3365 mL | 1.6826 mL | 3.3651 mL | 8.4128 mL | |
| 20 mM | 0.2524 mL | 1.2619 mL | 2.5239 mL | 6.3096 mL | |
| 25 mM | 0.2019 mL | 1.0095 mL | 2.0191 mL | 5.0477 mL | |
| 30 mM | 0.1683 mL | 0.8413 mL | 1.6826 mL | 4.2064 mL | |
| 40 mM | 0.1262 mL | 0.6310 mL | 1.2619 mL | 3.1548 mL | |
| 50 mM | 0.1010 mL | 0.5048 mL | 1.0095 mL | 2.5239 mL | |
| 60 mM | 0.0841 mL | 0.4206 mL | 0.8413 mL | 2.1032 mL | |
| 80 mM | 0.0631 mL | 0.3155 mL | 0.6310 mL | 1.5774 mL | |
| 100 mM | 0.0505 mL | 0.2524 mL | 0.5048 mL | 1.2619 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.