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Cat. No.: HY-183005

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ActRIIB-IN-1

ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC₅₀ of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia.

For research use only. We do not sell to patients.

CAS No.: 3039974-31-4
Formula: C₂₁H₂₂N₆
Molecular Weight:358.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-1 Chemical Structure

CAS No.: 3039974-31-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TGF-β Receptor Isoforms :

In Vitro

ActRIIB-IN-1 (Compound 2) (1.25-5 μM; 48 h) alleviates C2C12 mature myotube atrophy induced by C26 cell culture medium^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C2C12 mature myotube
Concentration:

1.25, 2.5, 5 μM
Incubation Time:

48 h
Result:

Showed atrophy reversal rate of 69.2, 97.61 and 130.63%.

In Vivo

ActRIIB-IN-1 (Compound 2) (5 mg/kg; i.g.; qd; 24 days) can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with C26 tumor cells^[1]
Dosage:

5 mg/kg
Administration:

i.g.; qd; 24 days
Result:

Alleviated weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite.
Did not inhibit tumor growth.

Chemical Information

CAS No. 3039974-31-4
Molecular Weight 358.45
Formula C₂₁H₂₂N₆
SMILES

N=1C=C(C=C2C1NC=C2C3=NNC=C3)C=4C=CC(=CC4)N5CCN(C)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiaochun Dong, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661. 2025-06-01

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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