KHK-IN-8
KHK-IN-8 is a selective KHK inhibitor, with an IC50 of 13.0 nM against hKHK-C and an IC50 of 22.7 nM against hKHK-A. KHK-IN-8 is applicable to research on non-alcoholic steatohepatitis, type 2 diabetes and obesity.
For research use only. We do not sell to patients.
- CAS No.: 3108075-72-2
- Formula: C22H24F3N5O2
- Molecular Weight:447.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hKHK-C 13.0 nM (IC50) |
hKHK-A 22.7 nM (IC50) |
KHK-IN-8 potently inhibits recombinant human KHK-C with an IC50 of 13.0 nM[1].
KHK-IN-8 has an apparent permeability of 23 × 10-6 cm/sec in a Caco-2 cell assay[1].
KHK-IN-8 inhibits F1P production in HepG2 cells with an IC50 of 156 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3108075-72-2
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Molecular Weight 447.45
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Formula C22H24F3N5O2
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SMILES
CN([C@H]1CCN(C2=NC(NC3=CC(CCC(O)=O)=CC=C3)=C(C#N)C(C(F)(F)F)=C2)C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KHK-IN-8 Related Classifications
HY-208737 Related Classifications
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