country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P992434

Copy Link Print Information

OSE-279

OSE-279 is a high-affinity humanized monoclonal bivalent antibody targeting PD-1, the recommended isotype control is HY-P99003. OSE-279 blocks PD-1 ligand binding, inhibits PDL1-induced SHP1 phosphorylation, restores T cell activation, and promotes reactivation of primary T cell effector functions. OSE-279 binds hFcRn receptor, predicts long half-life, induces CD4 and CD8 T cell proliferation, and promotes interleukin 2 and interferon gamma secretion. OSE-279 can be used for the research of advanced malignancies, colon cancer, hepatocarcinoma, mesothelioma.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OSE-279 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]

IL-2

All Interleukin Related Isoforms :

In Vitro

OSE-279 blocks PD-1 binding to PD-L1 with an IC₅₀ of 308 ng/mL and to PD-L2 with an IC₅₀ of 911 ng/mL in cell-free binding assays^[2].
OSE-279 inhibits PD-L1-induced SHP1 phosphorylation in a cell-based assay with an IC₅₀ of 14.19 ng/mL^[1].
OSE-279 reactivates primary T cell effector functions in an MLR assay, inducing interleukin 2 and interferon γ secretion^[1].
OSE-279 shows good affinity to the human FcRn receptor, predicting a long half-life in humans^[1].
OSE-279 restores T cell activation via inhibition of pSHP-1 signalling in cell-based assayS^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OSE-279 exerts potent antitumor activity with long-term responses and improved survival in syngeneic colon cancer, hepatocarcinoma, and mesothelioma models in immunocompetent PD1 Knock-in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

5133 [NCBI]

Accession

Q15116

Target

PDCD1/PD-1/CD279

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Philippe Cassier, et al. Abstract C063: OSE279, a PD-1 blockingmonoclonal antibody, as future backbone of a bifunctional checkpoint inhibitor platform:Preclinical characterization and early clinical results of a First-In-Human (FIH) study in subjectswith advanced malignancies [abstract]. In: Proceedings of the AACR-NCI-EORTC VirtualInternational Conference on Molecular Targets and Cancer Therapeutics. Mol Cancer Ther (2023) 22 (12 Supplement): C063.

[2]. Robert M, et al. A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics, and pharmacodynamics of OSE-279, an anti-PD-1 monoclonal antibody in patients with advanced solid tumours. Eur J Cancer. 2026;240:116729. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

OSE-279

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

OSE-279 Related Classifications

HY-P992434 Related Classifications