Sergliflozin-A
Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.
For research use only. We do not sell to patients.
- CAS No.: 360775-96-8
- Formula: C20H24O7
- Molecular Weight:376.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
SGLT1 |
SGLT2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
9.2 nM
Compound: 4a
|
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
|
[PMID: 18260618] |
| CHO | EC50 |
>8000 nM
Compound: 4a
|
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
|
[PMID: 18260618] |
| CHO | IC50 |
6.25 nM
Compound: 6
|
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
|
[PMID: 20181486] |
| CHO | IC50 |
2300 nM
Compound: 3-active
|
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
|
[PMID: 21873071] |
| CHO | IC50 |
4.8 nM
Compound: 3-active
|
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
|
[PMID: 21873071] |
| CHO-K1 | IC50 |
2300 nM
Compound: 2-A
|
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
|
[PMID: 22652255] |
| CHO-K1 | IC50 |
4.8 nM
Compound: 2-A
|
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
|
[PMID: 22652255] |
Chemical Information
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CAS No. 360775-96-8
-
Molecular Weight 376.40
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Formula C20H24O7
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SMILES
COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)