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Cat. No.: HY-183788

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EGFR-IN-212

EGFR-IN-212 is an EGFR inhibitor with human IC₅₀ values of 1.83 μM. EGFR-IN-212 reduces EGFR mRNA expression and induces apoptosis. EGFR-IN-212 can be used for the research of non-small cell lung carcinoma.

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Formule: C₂₂H₂₅N₅S
Masse moléculaire:391.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-212 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

EGFR-IN-212 (Compound 2a) (3.9-125 μM; 24 h) potently inhibits the viability of A549 human lung adenocarcinoma cells with an IC₅₀ of 20.51 μM^[1].
EGFR-IN-212 (20.51 μM; 24 h) induces both early (2.3%) and late (6.7%) apoptosis in A549 human lung adenocarcinoma cells^[1].
EGFR-IN-212 (24 h) potently inhibits EGFR activity in A549 human lung adenocarcinoma cells with an IC₅₀ of 1.83 μM^[1].
EGFR-IN-212 notably decreases EGFR mRNA expression in A549 human lung adenocarcinoma cells^[1].
EGFR-IN-212 binds to the human EGFR tyrosine kinase domain (PDB ID: 1M17) with a docking score of -4.352 kcal/mol, forming key interactions with the Met769 and Glu780 residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

A549 human lung adenocarcinoma cells
Concentration:

20.51 μM
Incubation Time:

24 h
Result:

Induced both early and late apoptosis in A549 cells: 2.3% of cells underwent early apoptosis, and 6.7% underwent late apoptosis, compared to untreated control cells.

Chemical Information

Masse moléculaire 391.53
Formule C₂₂H₂₅N₅S
SMILES

CN1CCN(CC2=CC=C(/C=N/NC3=NC(C4=CC=CC=C4)=CS3)C=C2)CC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Altıntop MD, et al. Development of a new series of thiazoles as EGFR-targeted anticancer agents for NSCLC therapy through nanotechnological and computer-aided approaches. Bioorg Chem. 2026;178:109938. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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