EGFR-IN-212
EGFR-IN-212 is an EGFR inhibitor with human IC50 values of 1.83 μM. EGFR-IN-212 reduces EGFR mRNA expression and induces apoptosis. EGFR-IN-212 can be used for the research of non-small cell lung carcinoma.
For research use only. We do not sell to patients.
- Formula: C22H25N5S
- Molecular Weight:391.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
EGFR-IN-212 (Compound 2a) (3.9-125 μM; 24 h) potently inhibits the viability of A549 human lung adenocarcinoma cells with an IC50 of 20.51 μM[1].
EGFR-IN-212 (20.51 μM; 24 h) induces both early (2.3%) and late (6.7%) apoptosis in A549 human lung adenocarcinoma cells[1].
EGFR-IN-212 (24 h) potently inhibits EGFR activity in A549 human lung adenocarcinoma cells with an IC50 of 1.83 μM[1].
EGFR-IN-212 notably decreases EGFR mRNA expression in A549 human lung adenocarcinoma cells[1].
EGFR-IN-212 binds to the human EGFR tyrosine kinase domain (PDB ID: 1M17) with a docking score of -4.352 kcal/mol, forming key interactions with the Met769 and Glu780 residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 human lung adenocarcinoma cells
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Concentration:20.51 μM
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Incubation Time:24 h
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Result:Induced both early and late apoptosis in A549 cells: 2.3% of cells underwent early apoptosis, and 6.7% underwent late apoptosis, compared to untreated control cells.
Chemical Information
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Molecular Weight 391.53
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Formula C22H25N5S
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SMILES
CN1CCN(CC2=CC=C(/C=N/NC3=NC(C4=CC=CC=C4)=CS3)C=C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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