CLPS - colipase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1208

About CLPS

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,794,982-35,797,323 (from NCBI)

This gene has 3 transcripts (splice variants), 135 orthologues and 3 paralogues. Restricted expression toward pancreas (RPKM 17741.6).

Summary

The protein encoded by this gene is a cofactor needed by pancreatic Lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of Lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows Lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CLPS Products (3)

mRNA Protein Name
NM_001252597.2 NP_001239526.1 colipase isoform 2
NM_001252598.2 NP_001239527.1 colipase isoform 3 preproprotein
NM_001832.4 NP_001823.1 colipase isoform 1 preproprotein

CLPS Protein Structure

Colipase

Colipase: Colipase, N-terminal domain (21 - 60)

Colipase_C

Colipase_C: Colipase, C-terminal domain (62 - 106)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

colipase

  • colipase, pancreatic

Recombinant CLPS Proteins

Cat. No. Product Name Accession Purity
HY-P72933 CLPS Protein, Human (sf9, His) P04118 (A18-Q112) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pancreas Disease

  • Abnormality Of The Pancreas

  • Pancreatic Diseases
Acute Pancreatitis

  • Pancreatitis

  • Pancreatitis, Acute Necrotizing

  • Pancreatitis Nos

  • Acute Pancreas Inflammation
Pancreatic Steatorrhea

  • Pancreatic Steatorrhoea

  • Decreased Tolerance Of Pancreas

  • Pancreatic Disturbance Of Fat Absorption
Johanson-Blizzard Syndrome

  • JBS

  • Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness

  • Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness

  • Johanson Blizzard Syndrome
Keratomalacia

  • Vitamin A Deficiency

  • Night Blindness

  • Retinol Deficiency

  • Xerotic Keratitis

  • VAD

  • Vitamin A

  • Hypovitaminosis A

  • Bitot Spots

  • Bitot Spots In The Young Child

  • Conjunctival Xerosis With Bitot'S Spots

  • Vitamin A Deficiency With Cornea Xerosis

  • Vitamin A Deficiency With Cornea Ulceration Or Xerosis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P1698B Reltecimod TFA 99.78% Phase 3

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103023 CLP290 Activator 99.96% Unkown
HY-110143 CLP257 Activator 99.31% Unkown
HY-N1388 Tussilagone 99.52% Unkown
HY-P1698 Reltecimod 98.62% Yes
HY-141487 CLP-3094 Inhibitor 99.92% Unkown
HY-178159 SA91-0178 Inhibitor 98.14% Unkown
HY-119102 BPU-11 98.08% Unkown
HY-149426 SIRT5 inhibitor 7 Inhibitor 99.66% Unkown
HY-163409 CGK012 Inhibitor 99.96% Unkown
HY-178136 MyD88-IN-3 Inhibitor 99.33% Unkown
HY-169059 Ferroptosis-IN-12 Inhibitor / Unkown
HY-P11617 CLP-d2 Inhibitor / Unkown
HY-RS02829 CLP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02832 CLPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18608 Clps Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19585 Clp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25094 Clps Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26082 Clp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CLPS VGNC VGNC:71264
Mus musculus CLPS MGD MGI:88421
Canis familiaris CLPS VGNC VGNC:54934
Rattus norvegicus CLPS RGD RGD:2363
Bos taurus CLPS VGNC VGNC:53963
Others CLPS NCBI