SRF - serum response factor Gene

Also Known as MCM1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6722

About SRF

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,171,269-43,181,506 (from NCBI)

This gene has 1 transcript (splice variant), 279 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 20.2), heart (RPKM 19.8) and 25 other tissues.

Summary

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-Fos, and thereby participates in cell cycle regulation, Apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SRF Products (2)

mRNA	Protein	Name
NM_001292001.2	NP_001278930.1	serum response factor isoform 2
NM_003131.4	NP_003122.1	serum response factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20808827	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	23764775	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	3203386	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18296735	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16054032	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1509260	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7854423	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	3203386	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables serum response element binding	IDA IDA: Inferred from direct assay	3203386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell myoblast differentiation	IGI IGI: Inferred from genetic interaction	19783823	GOA
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	15180964	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	15282327	GOA
involved in negative regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	19098903	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19098903	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18296735	GOA
acts upstream of or within positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	17576768	GOA
involved in positive regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	23764775	GOA
involved in positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	17215356	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17576768	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	3203386	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19783823	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	8887666	GOA
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	15180964	GOA
involved in response to hormone	IDA IDA: Inferred from direct assay	17975004	GOA
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19098903	GOA
acts upstream of or within trophectodermal cell differentiation	IDA IDA: Inferred from direct assay	17576768	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	2108863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRF Protein Structure

SRF-TF

0
100
200
300
400
508 a.a.

Protein Preferred Names	Protein Names
serum response factor	c-fos serum response element-binding transcription factor

SRF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRF	P11831	GTF2F1	Homo sapiens	P35269	Y2H	7854423
Intra	SRF	P11831	MRTFB	Homo sapiens	Q9ULH7	Anti Tag CoIP	14565952
Intra	SRF	P11831	MRTFB	Homo sapiens	Q9ULH7	Pull Down	12397177
Intra	SRF	P11831	MRTFA	Homo sapiens	Q969V6	Pull Down	12397177
Intra	SRF	P11831	MYOCD	Homo sapiens	Q8IZQ8	Comig Non-Denat Gel	12397177

Cross: Cross-species interaction Intra: Intraspecies interaction

SRF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87085	SRF Antibody (YA6778)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Miller Fisher Syndrome	Cranial Variant Of Gbs Fisher'S Syndrome Miller-Fisher Variant Of Guillain-Barre Syndrome Miller-Fisher Syndrome Cranial Variant Of Guillain-Barré Syndrome Cranial Variant Of Guillain-Barre Syndrome Fisher Syndrome
Myopericytoma
Myofibroma	Lipoleiomyoma Uterine Fibroids Solitary Myofibromatosis Myolipoma
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Muscle Hypertrophy	MSLHP Hypertrophy Hypertrophy, Muscle
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Chondroid Lipoma
Megabladder, Congenital	MGBL Congenital Megabladder
Rheumatoid Vasculitis
Brachydactyly, Type E1	Brachydactyly Type E1 Brachydactyly Type E BDE1 Brachydactyly, Type E Bde Type E Brachydactyly Brachydactyly E1 Brachydactyly Syndrome Type E
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Dyslexia
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990068	Perenostobart	Inhibitor	97.00%	Phase 2
HY-P990024	Casdozokitug	Inhibitor	96.49%	Phase 2
HY-P99533	Urabrelimab	Inhibitor	99.487%	Phase 1
HY-P991061	Tagmokitug	Inhibitor	99.9%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13991	CCG-1423		99.88%	Unkown
HY-108361	CCG-203971	Inhibitor	99.89%	Unkown
HY-120855	CCG-100602	Inhibitor	99.29%	Unkown
HY-132187	Sphingosylphosphorylcholine		99.50%	Unkown
HY-111432	CCG-232601	Inhibitor	99.00%	Unkown
HY-162904	BPU17		98.16%	Unkown
HY-118748	Suprafenacine	Inhibitor	98.0%	Unkown
HY-153078	MRTF/SRF-IN-1	Inhibitor	99.68%	Unkown
HY-130011	CCG-232964	Inhibitor	/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-RS13760	SRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17529	Srf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23985	Srf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRF	RGD	RGD:1559787
Mus musculus	SRF	MGD	MGI:106658
Macaca mulatta	SRF	VGNC	VGNC:77882
Canis familiaris	SRF	VGNC	VGNC:46799
Bos taurus	SRF	VGNC	VGNC:35277
Felis catus	SRF	VGNC	VGNC:65678
Others	SRF	NCBI