TK1 - thymidine kinase 1 Gene

Also Known as TK2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7083

About TK1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,174,079-78,187,204 (from NCBI)

This gene has 6 transcripts (splice variants) and 209 orthologues. Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 12.6) and 18 other tissues.

Summary

The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]

TK1 Products (3)

mRNA	Protein	Name
NM_001346663.2	NP_001333592.1	thymidine kinase, cytosolic isoform 2
NM_001363848.1	NP_001350777.1	thymidine kinase, cytosolic isoform 3
NM_003258.5	NP_003249.3	thymidine kinase, cytosolic isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables thymidine kinase activity	IDA IDA: Inferred from direct assay	14697231	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17407781	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA synthesis involved in mitotic DNA replication	IDA IDA: Inferred from direct assay	14697231	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	14697231	GOA
involved in protein homotetramerization	IPI IPI: Inferred from physical interaction	17407781	GOA
involved in thymidine biosynthetic process	IDA IDA: Inferred from direct assay	14697231	GOA
involved in thymidine metabolic process	IDA IDA: Inferred from direct assay	22385435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TK1 Protein Structure

0
100
200
234 a.a.

Protein Preferred Names	Protein Names
thymidine kinase, cytosolic	cytosolic thymidine kinase

TK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TK1	P04183	MAGEA4	Homo sapiens	Q1RN33	Y2H Prey Pooling	25416956
Intra	TK1	P04183	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	TK1	P04183	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	TK1	P04183	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	TK1	P04183	TK1	Homo sapiens	P04183	X-Ray Diffraction	22385435
Intra	TK1	P04183	APLP1	Homo sapiens	P51693	Y2H	21900206
Intra	TK1	P04183	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	TK1	P04183	COPS6	Homo sapiens	Q7L5N1	Y2H Pooling	16169070
Intra	TK1	P04183	APLP1	Homo sapiens	P51693	Y2H Pooling	16169070
Intra	TK1	P04183	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	TK1	P04183	CCDC90B	Homo sapiens	Q9GZT6	Y2H Pooling	16169070
Intra	TK1	P04183	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	TK1	P04183	CRMP1	Homo sapiens	Q14194	Y2H Pooling	16169070
Intra	TK1	P04183	COPS6	Homo sapiens	Q7L5N1	Y2H	21900206
Intra	TK1	P04183	TK1	Homo sapiens	P04183	Y2H	21900206

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71074	Thymidine kinase 1/TK1 Protein, Human (HEK293, His)	P04183 (M1-N234)	≥ 95%, as determined by reducing SDS-PAGE.

TK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82450	Thymidine Kinase Antibody (YA2195)	WB, IP	Human
HY-P82450A	Thymidine Kinase Antibody (YA2195)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Hypochondroplasia	HCH Hypochondrodysplasia Chondrogenesis Imperfecta Hypochondroplastic Dwarfism Hypochondroplastic Short Stature
Thanatophoric Dysplasia, Type I	Thanatophoric Dysplasia Thanatophoric Dwarfism Thanatophoric Dysplasia Type 1 TD1 Td Thanatophoric Short Stature Thanatophoric Dwarfism Type 1 Thanatophoric Dysplasia Type I Platyspondylic Lethal Skeletal Dysplasia, San Diego Type Lethal Short-Limbed Platyspondylic Dwarfism, San Diego Type Skeletal Dysplasia, San Diego Type Plsd San Diego Type Thanatophoric Dwarfism 1 Dwarfism Thanatophoric Dwarf, Thanatophoric Thanatophoric Dysplasia 1 Lethal Short-Limbed Platyspondylic Dwarfism San Diego Type Platyspondylic Lethal Skeletal Dysplasia San Diego Type Thanatophoric Dwarf Thanatophoric Dwarfism Or Short Stature Thanatophoric Dwarfism Syndrome Td - [Thanatophoric Dwarfism]
Achondroplasia	Achondroplastic Dwarfism ACH Osteosclerosis Congenita Achondroplastic Physique Chondrodystrophia Dwarf, Achondroplastic Achondroplastic Short Stature Congenital Osteosclerosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Mitochondrial Dna Depletion Syndrome 2	Mitochondrial Dna Depletion Syndrome, Myopathic Form MTDPS2 Tk2-Related Mitochondrial Dna Depletion Syndrome, Myopathic Form Mitochondrial Dna Depletion Myopathy, Tk2-Related Tk2-Related Mitochondrial Dna Depletion Myopathy Mtdna Depletion Syndrome, Myopathic Form Mitochondrial Dna Depletion Myopathy Tk2-Related Mitochondrial Dna Depletion Syndrome 2 Myopathic Type Myopathic Mitochondrial Dna Depletion Syndrome Mitochondrial Dna Depletion Syndrome, Type 2
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Mitochondrial Dna Depletion Syndrome	Mtdna Depletion Syndrome
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W342664	2'-Deoxy-2'-fluoro-5-iodouridine		99.46%	Unkown
HY-128710	2'-Fluorothymidine		99.07%	Unkown
HY-104083	North-methanocarbathymidine	Inhibitor	/	Unkown
HY-RS14556	TK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W770090	CF 1743-d7	Inhibitor	/	Unkown
HY-107025	Cf1743		99.44%	Unkown
HY-128710R	2'-Fluorothymidine (Standard)		/	Unkown
HY-RS17046	Tk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23490	Tk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TK1	MGD	MGI:98763
Canis familiaris	TK1	VGNC	VGNC:47389
Rattus norvegicus	TK1	RGD	RGD:621014
Macaca mulatta	TK1	VGNC	VGNC:78361
Felis catus	TK1	VGNC	VGNC:66201
Bos taurus	TK1	VGNC	VGNC:35884
Others	TK1	NCBI