Ro 24-5913
Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.
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- No. CAS: 128312-51-6
- Fòrmula: C23H28N2O3S
- Peso molecular:412.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 6.4 nM (LTD4)[1]
Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1]. Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Guinea pigs[1]
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Dosage:10 mg/kg
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Administration:Oral gavage; 10 mg/kg once
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Result:Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.
Chemical Information
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No. CAS 128312-51-6
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Peso molecular 412.55
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Fòrmula C23H28N2O3S
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SMILES
OC(C(CC)(CC)CC(NC1=CC=CC(/C=C/C2=NC(C3CCC3)=CS2)=C1)=O)=O
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Synonyms
Cinalukast
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 24-5913 Related Classifications
HY-107611 Related Classifications
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