Nr5a1 - nuclear receptor subfamily 5, group A, member 1 Gene

Also Known as Sf-1; Ad4bp; Ftzf1; Ad4BP/SF-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83826

Summary

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including calcineurin-mediated signaling; positive regulation of male gonad development; and response to gonadotropin-releasing hormone. Located in nucleus. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr5a1 Products (1)

mRNA Protein Name
NM_001191099.2 NP_001178028.1 steroidogenic factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12697699 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
12697699 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12697699 RGD
Biological Process GO Annotation Evidence References Source
involved in calcineurin-mediated signaling IMP
IMP: Inferred from mutant phenotype
25057110 RGD
involved in female gonad development IEP
IEP: Inferred from expression pattern
12865342 RGD
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
25057110 RGD
involved in positive regulation of male gonad development IMP
IMP: Inferred from mutant phenotype
16467257 RGD
involved in response to gonadotropin-releasing hormone IEP
IEP: Inferred from expression pattern
17344471 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12697699 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

steroidogenic factor 1

  • STF-1

  • adrenal 4-binding protein

  • fushi tarazu factor homolog 1

  • steroid hormone receptor Ad4BP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115613 ML-180 Inhibitor 99.96% Unkown
HY-131445 RJW100 Activator 99.93% Unkown
HY-107404 SID 7969543 Inhibitor 99.12% Unkown
HY-134462A RJW103 TFA Agonist / Unkown
HY-134462 RJW103 Agonist 98.71% Unkown
HY-402601 Desethyl-SID 7969543 Control 98.83% Unkown
HY-RS09553 NR5A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17509 Nr5a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23966 Nr5a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr5a1 NCBI NCBI:2516