RJW103 TFA

Cat. No.: HY-134462A: Data Sheet
SDS
Handling Instructions
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RJW103 TFA is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC₅₀ values of 6.5 and 5.9, respectively. RJW103 TFA activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 TFA can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors.

For research use only. We do not sell to patients.

RJW103 TFA Chemical Structure

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of RJW103 TFA:

RJW103

Other Forms of RJW103 TFA:

RJW103 In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

RJW103 TFA (10 μM; 24 h) activates SF-1-mediated transcription of SHP, StAR, G0S2, and MeOX1 in mSF-1-expressing HEK293 cells, and activates LRH-1-mediated transcription of StAR and G0S2 (but not SHP or MeOX1) in hLRH-1-expressing HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	HEK293 cells stably expressing mouse SF-1, HEK293 cells stably expressing human LRH-1
Concentration:	10 μM
Incubation Time:	24 h
Result:	Significantly increased mRNA levels of SHP, StAR, G0S2, and MeOX1 in mouse SF-1-expressing HEK293 cells. Significantly increased mRNA levels of StAR and G0S2, but did not activate SHP or MeOX1, in human LRH-1-expressing HEK293 cells.

Molecular Weight

499.61

Formula

C₃₀H₃₆F₃NO₂

Appearance

Oil

SMILES

C=C(C1=CC=CC=C1)[C@]23C(C4=CC=CC=C4)=C(C[C@]2(CN(C3)C)[H])CCCCCC.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Data Sheet (276 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Whitby RJ, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011;54(7):2266-2281. [Content Brief]

[2]. Wu T, et al. Liver receptor homolog-1: structures, related diseases, and drug discovery. Acta Pharmacol Sin. 2024;45(8):1571-1581.

RJW103 TFA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RJW103RJW 103RJW-103Orphan Nuclear Receptorsteroidogenic factor-1 activatorHEK293 cellsInhibitorinhibitorinhibit

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