SID 7969543 

SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC₅₀ of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC₅₀ of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily^[1][2].

SID 7969543 shows IC₅₀s of >33,333 nM for RORα, VP-16, respectively^[1].
SID 7969543 is assayed for functional activity against HEK 293T cells co-transfected with a plasmid encoding full length SF-1 and a second vector allowing expression of the luciferase gene under control of five tandem repeats of the natural SF-1 response element (SFRE). SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 values of 30 ± 15 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

452.46

C₂₄H₂₄N₂O₇

868224-64-0

Solid

White to off-white

CCOC(C(C)OC1=C2C(C(N(CC(NC3=CC=C(OCCO4)C4=C3)=O)C=C2)=O)=CC=C1)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784.  [Content Brief]

  [2]. Roth J, et al. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg Med Chem Lett. 2008;18(8):2628-2632.  [Content Brief]