Referencia número: HY-112909

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UAMC-3203

(Synonyms: FXT-001)

10 Cited Publications

Revisión del cliente

Based on 10 publication(s) in Google Scholar

UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC₅₀ of 12 nM.

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Pureza: 99.92%
No. CAS: 2271358-64-4
Fòrmula: C₂₅H₃₇N₅O₂S
Peso molecular:471.66

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

UAMC-3203 Chemical Structure

No. CAS: 2271358-64-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (10)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC₅₀ of 12 nM.

IC₅₀ & Target

IC50: 12 nM (Ferroptosis)^[1]

In Vivo

No toxicity is observed in mice after repeated injections of UAMC-3203 (20 μmol/kg; injected intraperitoneally; daily, over a period of 4 weeks)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild type mice derived from a Gpx4 fl/fl breeding^[1]
Dosage:

20 µmol/kg
Administration:

Injected intraperitoneally; daily, over a period of 4 weeks
Result:

No toxicity was observed.

Chemical Information

No. CAS 2271358-64-4
Appearance Solid
Peso molecular 471.66
Fòrmula C₂₅H₃₇N₅O₂S
Color White to off-white
SMILES

O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O
Synonyms

FXT-001
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (10)

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Journal Impact Factor

Nat Cell Biol

A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis. [Abstract]

2025 Aug;27(8):1288-1300. PMID: 40681752
Cell Death Differ

PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury. [Abstract]

2025 Oct 7. PMID: 41057687
Acta Neuropathol

Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury. [Abstract]

2024 Jun 22;147(1):106. PMID: 38907771
Acta Neuropathol Commun

Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS. [Abstract]

2023 Jul 25;11(1):121. PMID: 37491291
Cell Biol Toxicol

Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. [Abstract]

2022 Jun;38(3):505-530. PMID: 34401974
Bioorg Chem

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]

2024 Jun:147:107412. PMID: 38696845
Sci Rep

UAMC-3203 inhibits ferroptosis and promotes functional recovery in rats with spinal cord injury. [Abstract]

2024 Aug 30;14(1):20180. PMID: 39215144

UAMC-3203 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2024 Aug 30;14(1):20180. [Abstract]

The expressions of NRF2 and HO-1 were detected by Western blot assays on day 3 after SCI treated with UAMC-3203 (5 mg/kg, i.p.).

UAMC-3203 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2024 Aug 30;14(1):20180. [Abstract]

DHE (dihydroethidium) staining of spinal cord tissue on day 1 after SCI treated with UAMC-3203 (5 mg/kg, i.p.).

UAMC-3203 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2024 Aug 30;14(1):20180. [Abstract]

HE-stained and LFB-stained transverse sections of spinal cords from sham group, SCI group, SCI + UAMC-3203 (5 mg/kg, i.p.) (U) group, and SCI + U + B group 28 days after the injury.

UAMC-3203 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2024 Aug 30;14(1):20180. [Abstract]

The concentration of IL-1β, IL-4, IL-10 and TNFα in sham group, SCI group, SCI + UAMC-3203 (5 mg/kg, i.p.) (U) group, and SCI + U + B 7 days after the injury.
J Neurochem

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [Abstract]

2025 Oct;169(10):e70246. PMID: 41017138
Res Sq

2024 Jul 09.
Research Square Print

October 26th, 2022.

Solvente y solubilidad

In Vitro:

DMSO : 250 mg/mL (530.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1202 mL

10.6009 mL

21.2017 mL

5 mM

0.4240 mL

2.1202 mL

4.2403 mL

10 mM

0.2120 mL

1.0601 mL

2.1202 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1202 mL	10.6009 mL	21.2017 mL	53.0043 mL
	5 mM	0.4240 mL	2.1202 mL	4.2403 mL	10.6009 mL
	10 mM	0.2120 mL	1.0601 mL	2.1202 mL	5.3004 mL
	15 mM	0.1413 mL	0.7067 mL	1.4134 mL	3.5336 mL
	20 mM	0.1060 mL	0.5300 mL	1.0601 mL	2.6502 mL
	25 mM	0.0848 mL	0.4240 mL	0.8481 mL	2.1202 mL
	30 mM	0.0707 mL	0.3534 mL	0.7067 mL	1.7668 mL
	40 mM	0.0530 mL	0.2650 mL	0.5300 mL	1.3251 mL
	50 mM	0.0424 mL	0.2120 mL	0.4240 mL	1.0601 mL
	60 mM	0.0353 mL	0.1767 mL	0.3534 mL	0.8834 mL
	80 mM	0.0265 mL	0.1325 mL	0.2650 mL	0.6626 mL
	100 mM	0.0212 mL	0.1060 mL	0.2120 mL	0.5300 mL

Keywords

UAMC-3203

10 Cited Publications

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UAMC-3203

Anti-Cancer Compound Library

Ferroptosis Compound Library

Highly Selective Inhibitors Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) UAMC-3203

Actividad biológica

Chemical Information

Publications (10)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

UAMC-3203

Anti-Cancer Compound Library

Ferroptosis Compound Library

Highly Selective Inhibitors Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) UAMC-3203

Actividad biológica

Chemical Information

Publications (10)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

UAMC-3203 Related Classifications

HY-112909 Related Classifications