Apraclonidine
Based on 3 publication(s) in Google Scholar
Apraclonidine (ALO 2145 (free base)), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution.
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- No. CAS: 66711-21-5
- Fòrmula: C9H10Cl2N4
- Peso molecular:245.11
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Apraclonidine
MoreVer todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
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α adrenergic receptor |
Apraclonidine (ALO 2145 (free base)) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male rabbits[3]
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Dosage:1.15%
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Administration:Apraclonidine (1.15%, single instillation)
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Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 66711-21-5
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Peso molecular 245.11
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Fòrmula C9H10Cl2N4
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SMILES
NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1
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Synonyms
ALO 2145 free base
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chim Acta
Bifunctional Ti4+-modified paper for selective extraction or removal of phospholipids and paper spray mass spectrometry for bioanalysis in urine and plasma. [Abstract]2023 Oct 16:1278:341673. PMID: 37709425 -
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Pureza y Documentación
Referencias
[1]. Subhashie Wijemanne, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci [Content Brief]
[2]. R V Searles, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999 Apr;58(4):220-6. [Content Brief]
[3]. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apraclonidine Related Classifications
HY-12720 Related Classifications
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