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Apraclonidine hydrochloride (Synonyms: ALO 2145)

Cat. No.: HY-12720A Purity: >98.0%
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Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.

For research use only. We do not sell to patients.

Apraclonidine hydrochloride Chemical Structure

Apraclonidine hydrochloride Chemical Structure

CAS No. : 73218-79-8

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].

In Vitro

Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].

In Vivo

Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2].

Molecular Weight

281.57

Formula

C₉H₁₁Cl₃N₄

CAS No.

73218-79-8

SMILES

NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (443.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5515 mL 17.7576 mL 35.5151 mL
5 mM 0.7103 mL 3.5515 mL 7.1030 mL
10 mM 0.3552 mL 1.7758 mL 3.5515 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ApraclonidineALO 2145ALO2145ALO-2145OthersintraocularpressuretopicalophthalmicsolutioneyeaqueoushumorInhibitorinhibitorinhibit

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Product name:
Apraclonidine hydrochloride
Cat. No.:
HY-12720A
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