Apraclonidine
Based on 3 publication(s) in Google Scholar
Apraclonidine (ALO 2145 (free base)), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution.
For research use only. We do not sell to patients.
- CAS No.: 66711-21-5
- Formula: C9H10Cl2N4
- Molecular Weight:245.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Apraclonidine
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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α adrenergic receptor |
In Vitro
Apraclonidine (ALO 2145 (free base)) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male rabbits[3]
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Dosage:1.15%
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Administration:Apraclonidine (1.15%, single instillation)
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Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 66711-21-5
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Molecular Weight 245.11
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Formula C9H10Cl2N4
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SMILES
NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1
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Synonyms
ALO 2145 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chim Acta
Bifunctional Ti4+-modified paper for selective extraction or removal of phospholipids and paper spray mass spectrometry for bioanalysis in urine and plasma. [Abstract]2023 Oct 16:1278:341673. PMID: 37709425 -
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Purity & Documentation
References
[1]. Subhashie Wijemanne, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci [Content Brief]
[2]. R V Searles, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999 Apr;58(4):220-6. [Content Brief]
[3]. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apraclonidine Related Classifications
HY-12720 Related Classifications
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