Batabulin sodium
Based on 1 Customer Validation
Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death.
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- Pureza: 99.76%
- No. CAS: 195533-98-3
- Fòrmula: C13H6F6NNaO3S
- Peso molecular:393.24
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
β-tubulin[1]
Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary[1].
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis[1].
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 cells
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Concentration:30 nM, 100 nM and 300 nM
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Incubation Time:24 hours
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Result:Showed an arrest at the G2/M cell-cycle boundary.
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Cell Line:MCF7 cells
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Concentration:30 nM, 100 nM and 300 nM
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Incubation Time:24 hours or 48 hours
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Result:25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells[1]
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Dosage:40 mg/kg
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Administration:Intraperitoneal injection; once per week; on days 5, 12, and 19
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Result:Impaired the growth of the drug-sensitive CCRF-CEM tumors.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 195533-98-3
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Appearance Solid
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Peso molecular 393.24
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Fòrmula C13H6F6NNaO3S
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Color Off-white to light yellow
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SMILES
O=S(C1=C(F)C(F)=C(F)C(F)=C1F)([N-]C2=CC=C(OC)C(F)=C2)=O.[Na+]
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Synonyms
T138067 sodium
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 125 mg/mL (317.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5430 mL | 12.7149 mL | 25.4298 mL | 63.5744 mL |
| 5 mM | 0.5086 mL | 2.5430 mL | 5.0860 mL | 12.7149 mL | |
| 10 mM | 0.2543 mL | 1.2715 mL | 2.5430 mL | 6.3574 mL | |
| 15 mM | 0.1695 mL | 0.8477 mL | 1.6953 mL | 4.2383 mL | |
| 20 mM | 0.1271 mL | 0.6357 mL | 1.2715 mL | 3.1787 mL | |
| 25 mM | 0.1017 mL | 0.5086 mL | 1.0172 mL | 2.5430 mL | |
| 30 mM | 0.0848 mL | 0.4238 mL | 0.8477 mL | 2.1191 mL | |
| 40 mM | 0.0636 mL | 0.3179 mL | 0.6357 mL | 1.5894 mL | |
| 50 mM | 0.0509 mL | 0.2543 mL | 0.5086 mL | 1.2715 mL | |
| 60 mM | 0.0424 mL | 0.2119 mL | 0.4238 mL | 1.0596 mL | |
| 80 mM | 0.0318 mL | 0.1589 mL | 0.3179 mL | 0.7947 mL | |
| 100 mM | 0.0254 mL | 0.1271 mL | 0.2543 mL | 0.6357 mL |
Batabulin sodium Related Classifications
HY-13563A Related Classifications
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